2007 Drugs Word Scramble

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2007 Drugs

New drugs for 2007

Question	Answer
Aliskiren (Tekturna)	Hypertension, renin inhibitor, suppresses Angiotensin I formation, oral pills, 150 mg daily
Ixabepilone (Ixempra)	new antineoplastic agent, Breast cancer, bind to tubulin -> arrests cells at G2/M phase -> apoptosis
Lisdexamfetamine (Vyvanse)	ADHD, prodrug, stimulates CNS, increases BP, need to monitor heart
Nebivolol (Bystolic)	Hypertension, beta adrenergic receptor blocker, might treat heart failure, unique - produces NO-dependent vasodilation
which of the extended usage Peni is taken orally?	Carbenicillin (Geocillin), other (Tirarcillin, pipercillin) are used IV
amoxicillin versus ampicillin?	amoxi - more polar, easier absorbed, might be taken with food, orally ampi - IV, if orally only on empty stomach, wider range than amoxicillin
what is the usage of ampicillin?	staph, strep, Listeria, H. influenza, Klebsiella, Salmonella, Shigella, E.Coli, Enterobacter
what do you know about Zosyn?	Zosyn = pipercillin + tazobactam, Tx of moderate to severe infections (E.Coli, Pseudomonas, H.influenza,Proteus), given IV, used for febrile neutropenia, gyno, bone, joint infections, septicemia, intra-abdominal
cephalexin (Keflex)	first generation cephalosporin
Cephradine (Velocef)	first generation cephalosporin
Cefadroxil (Duricef)	first generation cephalosporin
Cefactor (Ceclor)	2nd generation cephalosporin
Cefoxitin (Mefoxin)	2nd generation cephalosporin
Cefuroxime (Ceftin)	2nd generation cephalosporin
Cefrodoxime (Vantin)	3rd generation cephalosporin
Ceftiazam (Recephin)	3rd generation cephalosporin
Cefotoxime (Cloforan)	3rd generation cephalosporin
Ceflazidime (Fortaz)	3rd generation cephalosporin
Cefipime (Maxipime)	4rd generation cephalosporin
what beta-lactam AB are used to treat life-threatening intra-abdominal infection?	Carbapenem, Azactam
antibiotic binding to 30 S subunit ...	inhibits tRNA function and block protein synthesis (example - tetra)
antibiotic binding to 50 S subunit ...	prevents translocation (example - Clindamycin and macrolides )
usage of Tetra (tetracycline, doxycycline, minocycline)..	broad: Gram + and -, Mycoplasma, Ricketsia, Chlamydia, AA, H. pylori
usage of Macrolides (azitro, claritro, erytro)...	narrow: Gram + cocci and bacilli, chlamydia (azitro),
what`s unique about Linezolid (Zyvox)	binds to 70S ribosome, inhibiting protein synthesis early on, no x-R with other AB
usage of Linezoid (Zyvox)	Gram + cocci, rods, methicliin- r and vancomycin -R staph
what`s a Synercid?	combo of streptogramins A and B, bind to 50S, used for methicillin-R Staph and Entero faecium
usage of Chloramphenicol?	wide: binds to 50S, TOXIC!!! -> aplastic anemia, gray baby, leukopenia, throbmocytopenia,
what is Atridox?	tetracycline derived AB, used for chronic adult perio
what is Arestin?	minocycline hydrochloride used for reduction of perio pockets
What is Periostat?	doxycylcine, used in perio for Tx of AA, adult periodontitis, inhibits collagenase activity
3 side effects of tetra?	superinfections, enamel hypoplasia, photosensitivity
what are tetracyclines drug interactions?	with penicillin -> reduced peni effect, with antiacid -> reduced tetra absorption,
name aminoglycosides	strepto, tobra, neo, kana, genta, netilMYCIN and amikacin
which group of drugs causes hearing loss, nephrotoxicity and neuromuscular blockage?	aminoglycosides (-mycins)
Paliperidone (Invega) 2006	Tx of schizophrenia, serotonergic and dopaminergic antagonist, oral, once a day
Rasagiline (Azilect) 2006	Tx of Parkinson’s D, inhibits MOA -> increase of dopa -> reduction of symptoms; oral, once/day.
adverse side effects of Rasagiline (Azilect)?	dry mouth, orthostatic hypotension, headache and weight loss.
Sitagliptin (Januvia) 2006	Tx of DM (II), more incretin -> inc insulin and decreased glucagon synthesis; oral, once/daily
Varenicline (Chantix) 2006	smoking cessation, nicotinic receptor agonist, binds to SERO+ DOPA receptors too, oral, dose changes
Posaconazole (Noxafil) 2006	antifungal, in HIV pt, inhibits ergosterol synthesis, orally in liquid form 3x/daily
side effects of Posaconazole (Noxafil)?	fever, diarrhea, nausea/vomiting, headache, mucositis, and arthralgia
Tigecycline (Tygacil) 2005	new AB (glycylcycline), binds to 30S, used for MRSA and VREF infections, intra-abdominal
Ramelteon (Rozerem) 2005	insomnia Tx, novel melatonin receptor agonist (for MT1 and MT2, no addiction
The dose of clindamycin for prophylaxis for bacterial endocarditis is ...?	600 mg
The dose of amoxicillin as standard prophylaxis for bacterial endocarditis or joint replacement implant pt is?	2g
according to ADA which dental procedures have high risk for bacteremia?	scaling, probing, ortho bands, perio surgery
Time to peak blood levels of penicillin VK after oral administration of tablets is ?	30 min to 1 hour
Augmentin = potassium clavulanate + ...?	AMX
what drug first isolated from a sewer pipe on the island of Sardinia?	cephalosporins
what is the first line antibiotic to treat late dental infections?	clindamycin
which drugs (dental AB) cause hypersensitivities?	penicillins (10%), then cephalosporins,
which drugs Increase the risk of “statin”-induced muscle breakdown and myalgia ?	macrolides (erythro, azithro, clarithro)
which drug should not be combined with alcohol (even 3 days after)?	metronidazole,
if pt is taking 8-10 drugs, what`s the chance for interaction?	20 out of 100
Subcutaneous injections: delivery time is ...?	10-15 minutes
give example of ligand gated channel?	nicotinic/Ach
give an example of metabotropic, G-protein coupled receptor?	muscarinic/Ach

Created by: fufik on 2008-09-06