Pain Management Word Scramble
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Question | Answer |
Mu receptors | produce analgesia, resp depression, sedation, euphoria, dependence, constipation |
K receptors | analgesia, resp depression, anxiety, hallucinations |
Delta receptors | analgesia without adverse events |
pure opioid agonists (mu mostly, some kapp) examples | fentanyl, hydromorphone, levophanol, mepiridine, methadone, morphine, oxycodone, oxymorphone |
moderate-mild opioids examples | codeine, hydrocodone, propoxyphene |
mixed agonist-antagonist (Kappa, weak on mu) examples | pentazocine, butophanol, nalbuphine, buprenorphine, dezocine |
Opioid antagonists that block but mu and kappa examples | Naloxone, Naltrexone, Nalmefene |
mixed agonist-antagonist effects | more euphoria, psychomimetic effects, less resp depression |
opioid antagonists effects | used to reverse resp depression and CNS depression |
opioid ADRs | CNS effects, chronic sedation, muscle jerks, changes in hormone levels, high doses create convulsions, resp depression, orthostatic hypotension, N/V, constipation, bladder spasm and urgency, urinary retention, flushing of face, sweating, pruritis |
opioids DDI | CNS depressants, anticholinergics, TCAs, atropine, antihypertensives, MAOI's |
ASA + APAP + Caffeine | Excedrin |
Abortive therapy for migraines | Ergotamine, Combinations with caffeine, Dihydroergotamine, triptans |
Ergotamine ADR | N/V, weakness in legs, myalgia, numbness/tingling, angina-like, tachycardia, bradycardia; overdose can cause ergotism -- ischemia, myalgias, parethesias, gangrene |
Ergotamine DDIs/Drug-dz interactions | SSRIs (separate by 24 hrs), Ci in renal or hepatic impairment, sepsis, CAD, PVD |
Ergotamine | Ergomar, Ergostat, Wigrettes, Gynergen, Medihaler-Mergotamine |
Ergotamine/Caffeine | Cafergot, Wigraine |
Ergotamine/pentobarbital/bellafoline | bellergal |
ergotamine/pentobarbital/belladona/caffeine | cafergot PB |
Isometheptene/dichloralphenazone/APAP | midrin |
Dihydroergotamine | little peripheral vasoconstriction, n/v or physical dependence but diarrhea predominant |
DHE CI | CAD, PVD, pregnancy, sepsis, hepatic or renal impairment; dont give within 24 hrs of SSRI |
Triptan ADR | tingling, parethesias, warmth of head, neck, chest, limbs, dizziness, flushing, back pain, stiffness, chest symptoms, heavy arms, agina (rarE), vertigo, malaise, fatigue |
Triptan DDI/D-DzI | ergots, triptans, MAOI's; CI in IHD, MI, uncontrolled HTN |
Almotriptan | Axert |
Sumatriptan | Imitrex |
Eletriptan | Relpax |
Frovatriptan | Frova |
Rizatriptan | Maxalt |
Zolmitriptan | Zomig |
Naratriptan | Amerg |
migraine prophylaxis | beta blockers, anticonvulsants, antidepressants, CCBs, methysergide |
Beta blockers in migraine prophylaxis | propranolol and timolol DOC |
Antidepressants in migraine prophyalxis | amitriptyline, fluoxetine |
Divalproex ADR | weight gain, hair loss, tremor, teratogenic |
Topiramate ADR | parethesia, fatigue, nausea, dizziness, difficulty concentration, wieght loss, anorexia |
Methysergide | ergot alkaloid |
Methyseride ADR | retroperitoneal, pleuropulmonary, cardiac fibrosis, vascular insufficiency, insomina, altered mood, depersonalization, hallucinations, nightmares, GI disturbances, N/V, diarrhea |
Created by:
cytoskeletor
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