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TLC Normaltotal lung capacity 6000ml
VT Normaltidal volume 500 ml
VC normalvital capacity 4800
RV normalresidual volume 1200
Volumes that cannot be directly measured in a PFTRV, FRC, TLC
Tests used for RV, FRC, and TLCHelium dilution, Nitrogen washout, body box (most accurate)
PFT Equipment for measuring volumewater sealed spirometer (uses bell) bellows spirometer (most popular) dry rolling seal spirometer
Infection Control in PFT'sstandard precautions fluids-hand washing, gloves, barrier filters. Infectious disease- personal respirator or close fitting mask (N-95 for TB). safe disposal, sterilize or disinfect equip between patients.
Why PFT'sidentify and quantify changes in pulm function, epidemiological surveillance for pulm disease, assessment of post op risk, determine pulm disability, evaluate and quantify therapeutic effectiveness
Patient instructions for FVCeffort dependent, careful instructions, be sure Pt understands and will cooperate, demonstrate, enthusiastic coaching, sitting standing ok, nose clips on or off ok, 3 tests, best 2 must be within 5% ( convert atps to btps)
ATPS to BTPSsince ATPS can be 5 to 15% different that BTPS, adjustments must be made or test will be invalid.
FEV1forced exp volume in 1 second, Normal is 4.2 L...(<80%=obstructive), measured as volume it is considered a flow. Used as a measure of general severity with airway obstruction
FEV2forced exp volume in 2 seconds, normal is 4.6L
FEV3forced exp volume in 3 seconds 4.8L
PEFRPeak exp flow rate, steepest point on curve on the "FLOOP", normal is 9.5L/sec (best identified on a flow-volume loop
FEF200-1200forced exp press between 200 and 1200, normal 8.5ml/second, measures large airway flow
FEF25-75forced exp flow between 25 and 75, normal is 4.5L/second, measures small airways
Measuring RVResidual Volume, normal 1200, like the FRC & TLC it cannot be directly measured. alternative tests are, 1.Body box 2. Helium dilution 3. Nitrogen washout
Body Boxbest method to measure RV, uses Boyles Law to calc RV, larger values because more accurate information
PFT Contra-indicationshemoptysis, pneumothorax, cardio problems, thoracic, abdominal or cerebral aneurysm, recent eye surgery, acute disease that may cause nausea or vomiting, recent ab or chest surgery
FVC Validity/Reliability3 acceptable tests must be given, best 2 should not vary by more than 5%, no cough, swallow or disruptions, smooth, continuous and complete, exhalation must be a minimum of 6 seconds
M V VMax voluntary ventilation, normal is 160L/min, tested with Spirogram, fast and hard for at least 12 seconds, 2x-use best results, tests for strength of muscles, flow and capacity, tested pre-op/ make sure patient can get of vent post op
PFT Severitynormal 80 - 120, moderate 50-64, very severe <35
Obstructive severitycheck FEV1 & FEV1%
Restrictive Severitycheck FVC, TLC & VC
DLCODiffusion of Lung Carbon Monoxide, normal is 40ml/min/mmHg, 0.3%CO & 10% He in air held in a single breath for 10 seconds.
Restrictive Disease↓ volumes & capacities, affects lung parenchyma and thoracic pump, ↓ inspiration, ↓CL, more vertical slope on PFT tracing than obstructive, restriction+diffusion=fibrosis
Obstructive Disease↓ Flows, ↑ CL, flatter curve on PFT tracing, affects airways, obstruction+diffusion=emphysema
FVCForced Vital Capacity, normal is 480 ml
FEV1%FEV1/FVC, normal is 75 to 85 % (<70%=obstruction)
VC/TLC%VC is normally 80% of TLC
Spirometery Value Factorsheight, age, gender, ethnicity, sometimes for extreme weight and altitude (may be reduced 12 to 15 % for non-white)
FVC Tracingsobstructive curve is flatter, restrictive curve is more vertical
Conditions that ↓ DLCO↓ DLCO is associated with emphysema , Fibrosis, restrictive diseases, carbohemoglobin polycythemia, CHF, anemia, pulm embolism, exercise
Airway Obstruction TestsFEF200-1200, normal is 8.5 L/sec, <80%=large airway disease. FEF25-75, normal is 4.5 L/sec,<80%=small airway disease. (FRC or RV >120%=airtrapping)
Patient EffortPatient efforts insures validity and reliability of tests. Tests that are not valid or reliable, can lead to misdiagnoses, mistreatments and poor outcomes
Reversibility of airway obstructionbefore and after treatment studies, FEV1 >15% indicates effective treatments
PFT categories (test types)lung vol and cap, flow rates through airways, ability of lungs to diffuse gases (DL)
Nitrogen washout testopen circuit (non-re breather), exhaled gas measured for N2, Patient breaths until little N2 remains, 2-5 mins normal, COPD longer (perforated ear drum will scew test)
Helium Dilution testmeasures RV,FRC,TLC...closed circuit, helium and O2, CO2 is absorbed by soda lime and )2 is added, Pt breaths until gas concentration is equalized 3-5 mins (20 mins in copd)
Fibrosisrestriction + diffusion
bronchoprovocation testingmethocholine induced asthma attack, positive response is FEV1 falls more than 20%, reversed with svn or mdi treatment