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drugs, microbes--Microbiology

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Question
Answer
Not sterilization - kills non-spore-forming pathogens and lowers overall microbe count; does not kill endospores or many nonpathogenic microbes   Pasteurization  
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Microbiostatic   Cold; slows the growth of microbes; Refrigeration 0-15C and freezing <0C  
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Lyophilization   freeze drying; preservation;  
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Not effective microbial control – many cells retain ability to grow when water is reintroduced   Desiccation  
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Desiccation   Gradual removal of water from cells, leads to metabolic inhibition  
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Ionizing radiation   used to sterilize medical supplies and food products; gamma rays, X-rays, cathode rays; deep penetrating power that has sufficient energy to cause electrons to leave their orbit, breaks DNA,  
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Filtration   Physical removal of microbes by passing a gas or liquid through filter  
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Used to sterilize heat sensitive liquids and air in hospital isolation units and industrial clean rooms   Filtration  
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Act as surfactants dissolving membrane lipids and coagulating proteins of vegetative bacterial cells and fungi   Alcohols; Ethyl, isopropyl in solutions of 50-95%; Intermediate level  
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Antiseptic at low concentrations; strong solutions are sporicidal   Hydrogen Peroxide  
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Hydrogen Peroxide   Produce highly reactive hydroxyl-free radicals that damage protein and DNA while also decomposing to O2 gas – toxic to anaerobes; Weak (3%) to strong (25%)  
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Detergents and Soaps   Quaternary ammonia compounds (quats) act as surfactants that alter membrane permeability of some bacteria and fungi  
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Heavy Metals   Solutions of silver and mercury kill vegetative cells in low concentrations by inactivating proteins; silver nitrate, silver  
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common metabolic products of aerobic spore-forming bacteria and fungi.   Antibiotics; molds in genera Penicillium and Cephalosporium;  
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By inhibiting the other microbes in the same habitat, antibiotic producers have less competition for nutrients and space.   Antibiotics  
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Penicillins and cephalosporins block synthesis of   peptidoglycan, causing the cell wall to lyse.  
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Polymyxins   interact with phospholipids and cause leakage, particularly in Gram-negative bacteria.  
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A cell with a damaged membrane dies from   disruption in metabolism or lysis.  
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usually have a selective action against procaryotes;   antimicrobics  
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Antibacterial drugs   antibiotics, synthetic drugs  
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Penicillin is the drug of choice for   Gram-positive cocci (streptococci) and some Gram-negative bacteria (meningococci and syphilis spirochete).  
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Penicillins Primary problems   allergies and resistant strains of bacteria  
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Interferons (INF)   Human-based glycoprotein produced primarily by fibroblasts and leukocytes  
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Drug Resistance   Adaptive response in which microorganisms begin to tolerate an amount of drug that would ordinarily be inhibitory; due to genetic versatility or variation; intrinsic and acquired  
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