Antineoplastic Agents - Aklylating Agents
Help!
|
|
|
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mechlorethamine (N-mustard) | Hodgkins & NHL | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Vesiant activity = skin blistering
🗑
|
||||||||
| Melphalan (N-mustard) | Breast & Ovarian cancer | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Vesicant
🗑
|
||||||||
| Chlorambucil (N-mustard) | CLL (po) | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Vesicant
🗑
|
||||||||
| Cyclophosphamide (N-mustard) | NHL, ALL, CLL, AML, CML | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Acrolein = Toxic metabolite --> hemorrhagic cystitis (
🗑
|
||||||||
| Ifosfamide (N-mustard) | same as Cyclophosphamide, but for pts w/ liver disfunction. Increased half-life = 7 hrs | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Acrolein = Toxic metabolite --> hemorrhagic cystitis (
🗑
|
||||||||
| Busulfan | CML | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | SE: Pulmonary fibrosis, hyperpimentation
🗑
|
||||||||
| Carmustine (Nitrosureas - IV) | Brain Tumors (very lipophilic), Multiple Myloma | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | CNS toxicity, Lymphocytopenia, Thrombocytopenia
🗑
|
||||||||
| Lomustine (Nitrosureas - PO) | Brain Tumors, Multiple Myloma | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | see carmustine
🗑
|
||||||||
| Streptozocin | Pancreatic Islet Tumors | Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. | Less BM toxicity, Renal & Hepato toxicity.
🗑
|
||||||||
| Dacarbazine | Hodgkins, SLL, Melanoma, Glioblastoma | MAO-I, also CYP activity | HTN rxns --> avoid tyramines & sympathomimetics
🗑
|
||||||||
| Procarbazine | Hodgkins, SLL, Melanoma, Glioblastoma | see dacarbazine | see dacarbazine
🗑
|
||||||||
| Cisplatin | Bladder, Testicular, Ovarian & Small Cell Lung Cancer | Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. | Ototo & Renal toxicity, neuropathy, BM suppression
🗑
|
||||||||
| Oxaliplatin | Bladder, Testicular, Ovarian & Small Cell Lung Cancer | Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. | Ototo & Renal Toxicity, neuropathy, BM suppression
🗑
|
||||||||
| Carboplatin | Colorectal Cancer | Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. | BM suppression. Minor: ototo & renal toxicity and neuropathy
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
ssherwo