NSAIDS and other analgesics, OA, RA
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| What do NSAIDS do? | Reduce pain, inflammation and fever
🗑
|
||||
| What kind of conditions are NSAIDS used to treat? | Acute: Gout, trauma, surgery
Chronic: RA, OA, Musculoskeletal complaints
🗑
|
||||
| What percentage of the over 65's have a regular prescription for nsaids? | 10 - 20%
🗑
|
||||
| What are the most common side effects of NSAIDs? | GI tract problems
🗑
|
||||
| what does the inflammatory response require for activation? | Inflammatory cell activation - leucocytes
Inflammatory cytokines - cytokines
🗑
|
||||
| What are the inflammatory mediators? | Cytokines, kinins, proteases, nitric oxide and vaso active amines (histamine, seratonin), complement
🗑
|
||||
| What is the principle action of paracetamol? | Inhibition of prostaglandin synethsis
🗑
|
||||
| WHy are COZ - 2 selective NSAIDS better than non - selective NSAIDS? | Cox-2 selective nsaids were thought to lead t anti-inflammatory effects without the GI side effects.
However, they also have a role in platelet function which can lead to more thrombo-embolic events - can only be used short term
🗑
|
||||
| What side effects affect the GI tract and why? | Dyspepsia, nausea, vomiting, ulcer formation (30-50%), intestinal irritation, haemorrhage (1%)
WHY: inhibition of protective prostaglandins - PGE2/PGI2 inhibit gastric acid secretion, increase mucosal blood flow and are cytoprotective
🗑
|
||||
| Adverse affects on the renal system? Why? | Intestinal nephrites, nephrotoxicity, renal failure >yrs
WHY: Inhibition of pGE2 and PGI2, mediated vasodilation of renal medulla, and glomeruli, decreased creatinine clearence
🗑
|
||||
| Other adverse side effects as a result of using NSAIDS? | Bronchospasm, skin rash, allergic reaction, worsen oa?
WHY: hypersensitivity, decreased regulation of articular cartilage
🗑
|
||||
| What are DMARDS? | Disease modifying anti- rheumatic drugs
🗑
|
||||
| How do DMARDS work? | Immune modulators - restore normal immune environment
Alter disease activity, outcome and progression, and provide symptom relief
Slow onset of action (weeks-months)
Require regular monitoring
🗑
|
||||
| Symptoms of Osteoarthritis? | Age or injury related cartilage damage
Pain and swelling
Cellular mechanism not well understood
Oedema on the joints
Heberden's nodes (distal interphalangeal joints)
Bouchard's nodes (proximal interphalangeal joints)
Symetrical
Polyarticular
🗑
|
||||
| Treatment of Osteoarthritis? | Paracetamol/NSAIDS
Physiotherapy
Exercise
Avoid weight gain
injection
joint replacement
🗑
|
||||
| NSAIDS interactions with oral anticoagulants? | increase risk of GI bleeding
All have anti platelets effects
🗑
|
||||
| Nsaids interaction with Anti-hypertensives? | Reduce hypotensive effect
🗑
|
||||
| Nsaids interaction with Diuretics? | Reduce diuretic affect
🗑
|
||||
| NSAIDS interaction with ACE inhibitors K+ sparing diuretics | Hyperkalaemia
🗑
|
||||
| NSAIDS interaction with Lithium? | Increases Lithium levels
🗑
|
||||
| NSAIDS with methotrexate? | Increase methotrexate levels
🗑
|
||||
| Symptoms of Rheumatoid Arthritis? | Progressive systemic inflammatory disease
joint erosion
multi-system extra-articular manifestations
Pain, swelling, stiffness
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
Sophie_dystectic
Popular Medical sets