WVSOM Skin System 2012- Jackson Immunology
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| What is the role of Langerhan's cells in the skin system? | They are APCs found in the epidermis which utilize MHC I and MHC II to activate T cells.
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| What is the role of keratinocytes in the skin system? | They are MHC I predominantly and activate T cells.
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| What are the associated immunological proteins with langerhans cells? | MHC class I and II, CD40,CAM,B7
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| What are the immuno proteins associated with Keratinocytes? | MHC I and II, CAM, Prostaglandins, IL-1,6,8 and TNFa
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| What is allergic contact dermatitis? | contact dermatitis is an inflammatory skin condition.
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| what is the biochemical/immunologic cause of allergic contact dermatitis? | the antigen binds the langerhans cell which then presents to a T cell. The T cell then causes inflammation.
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| what are the three immunobullous diseases? | Bullous Pemphigoid, Pemphigus,Dermatitis herpetiformis
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| What immunoglobulin is associated with Bullous Pempphigoid? | IgG; subepidermal in location. Antibody against keratinocyte antigens.
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| how do you treat bullous pemphigoid? | corticosteroids
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| what is the histological appearance of a skin sample with bullous pemphigoid? | Total seperation of epidermis from the dermis.
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| what is pemphigus? | Widespread blistering of skin and mucous membranes that involved autoantibodies against keratinocyte antigens.
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| what is the treatment for pemphigus? | corticosteroids or azathiprine
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| what is intraepidermal acantholysis? | seperation of the dermis and epidermis
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| what is dermatitis herpetiformis? | associated with CELIAC DISEASE; pruritic vesicles that may appear on elbows, knees, back, neck or buttocks.
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| What is the histological marker in dermatitis herpetiformis? | IgA deposits at dermal- epidermal junction
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| What is the definition of Psoriasis? | sharply demarcated with clear borders, silvery scales, positive auspitz sign.
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| what is auspitz sign? | Puncuate bleeding when scales are ripped off
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| what is Koebner phenomenon? | linear presentation of rash
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| what is the pathogenesis of Psoriasis? | T cell mediated process that causes an increased rate of proliferation and shedding of keratinocytes
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| What do you use to treat Psoriasis? | UV light, PUVA, Steroids, retinoids, methotrexate
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| what are the biologic targets of therapies for Psoriasis? | TNFa, TH17
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