RBC - Test 1
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What is the 4 functions of RBCs? | 1. Transportation 2. Hemostasis - Clotting and Fluidity 3. Homeostasis 4. Carbonic Anhydrase - catalyst for CO2 and H20 reactions
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| What is the shape and structure of a RBC | RBCs have a round biconcave disc that allows it deform allowing it to pass through capillaries which have about the same diameter of 7.8 micrometers
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| What is the concentration of RBC's in men? | 5,200,000 mm3 (+ 3,000,000 varying according to size of individual, activity levels, and elevation)
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| What is the concentration of RBC's in women? | 4,700,000 mm3 (+ 3,000,000 varying according to size of individual, activity levels, and elevation)
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| Hematocrit separates what? | Hematocrits separates the plasma from the formed elements in blood?
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| What is the normal ranges for men and women of the formed elements in a hemotacrit? | 40% + or - 5%
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| What is the ratio of hemoglobin in males? | 16gm/dl
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| What is the ratio of hemoglobin in females? | 12-13 gm/dl
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| 1 gram of hemoglobin can carry how many ml of oxygen? | 1.34ml
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| What is the O2 carrying capacity for males? | 20 ml
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| What is the O2 carrying capacity for females? | 19 ml
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| Q: ______________ a stimulus for red cell production? | Erythropoietin
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| Erythrocyte count, Hematocrit, and Hemoglobin are usually higher or lower in men than in women? | Higher
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| What vitamin enhances the absorption of iron? | Vitamin C
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| What is the end product of RBC degradation? | bilirubin
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| What is hematocrit? | ratio of cells to fluid in the blood
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| What is the most abundant constituent of blood? | H20
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| Which of the following is a major site of RBC production in an adult? | Iliac Crest
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| Where is RBC production happening mid trimester gestation? | 1. Liver 2. Spleen 3. Lymph Nodes
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| Where is RBC production during adulthood? | 1. Vertebrae 2. Sternum 3. Ribs 4. Ilia
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| What is the largest fraction of the blood volume? | plasma
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| What is the first site of production for red blood cells? | yolk sac
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| The majority of iron found in the body is in what form? | hemoglobin
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| What is the normal lifespan of a red blood cell? | 4 months
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| As RBC's mature do they get bigger or smaller? | Smaller - think as you get old and decrepit you get smaller
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| What is Myeloid? | Blood producing tissue
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| Where are pluripotent hemopoietic stem cells found? | Bone Marrow
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| What is a CFU? | Colony forming unit
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| What promotes growth and reproduction of all stem cell types? | Interleukin 3
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| What does pro or blast mean? | Immature
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| Name the stages of RBC Genesis? | 1. Proerythroblast 2. Basophil Erythroblast 3. Polychromatophil erythroblast 4. Orthochromatic Erythroblast 5. Reticulocyte 6. Erythrocyte
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| What is the most essential regulator of RBC's | Tissue Oxygenation
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| Decreased tissue O2, increases or decreases RBC production? | Increases
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| What is the primary site for Erythropoietin | Kidneys
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| Erythropoietin responds to: | 1. Hypoxia - decreased O2 in tissue 2. nonrenal sensors in the body 3. norepinephrine 4. epinephrine 5. prostaglandins
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| What % of erythropoetin is formed in the kidneys? % in liver? | 90% in Kindney 10% in Liver
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| Folic acid and what vitamin are necessary for RBC maturation? | Vitamin B12
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| What foods are rich in Vitamin B12? | Animal products
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| How long is B12 stored in the liver | 3-4 years
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| What foods are rich in folic acid? | Green Vegetables, Fruits, and Liver
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| What are the 4 variations of hemoglobin? | 1. Alpha Chain 2. Beta Chain 3. Gamma Chain 4. Delta Chain
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| Hemoglobin consists of 2 _______ chains and 2 _________ chains? | 1. Alpha 2. Beta
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| 1 Hemoglobin molecule = | 4 heme subunits and 4 iron atoms which can carry 4 O2 molecules or 8 O2 atoms
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| How many grams of Iron is in the human body? | 4-5 Grams
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| What % of Iron is in the form of hemoglobin? | 65%
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| What is the approximate adult concentration of red blood cells per cubic millimeter? | 5,000,000
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| In human development, where is the original site for red blood production? | yolk sac
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| Q: ______________ areevidence of immature red blood cells? | Retics
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| Which of the following percentages is a normal hematocrit for a male? | 40%
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| What is the most common form of adult hemoglobin? | hemoglobin A
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| The spleen, kuppfer cells, and bone marrow will will phagocytize hemoglobin, True or False? | True
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