Neuro concepts 1 of 3
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rupture of this artery --> epidural bleed | middle meningeal artery
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CSF - how much made each day, how much ciruclating in brain at any time | 600 mL produced by chorioid plexus of pia mater. 130 mL circulating before resorbed into arachnoid villia
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CSF pressure, properties | 12mmHg, similar to plasma with lower protein count. No RBCs, 0-5 WBCs. protects, lubricates
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lumbar puncture taken from where | between 3-4th lumbar vertebrae subarachnoid space, ventriculostomy of 3rd or lateral ventrical
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What % of CO goes to brain, what molecule regulates vasodilation | 20%. C02 is regulator/vasodilator. If cerebral C02 increased-->vasodil to get more blood to brain. Decreased C02 --> vasoCon
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Cerebral circulation - does blood move forward and backwards? | no, circulation ALWAYS moves forward
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Which cerebral arter is site of major strokes | middle cerebral artery
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path of cerbral circulation | internal carotids --> anterior & middle cerebral arteries -->vertebral arteries fuse into basilar artery --> branches to posterior cerebral artery. Both internal caratoids also interconnected with anterior/posterior communicating arteries
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Circle of Willis | provides back-up circulation by providing interconnections between internal carotid arteries and basilar artery
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Where does cerebral blood drain | into venous plexuses, dural sinuses then to juglars
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Most veins in brain located where | located OUTSIDE of skull-->external jugular
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Venous sinuses located where | located INSIDE skull--> internal jugular
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occlusion of anterior cerebral artery impacts what region of brain | frontal, parietal lobes (basal ganglia, corpous callosum)
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condition caused by occlusion of anterior cerebral artery | hemiplegia on contralateral side
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occlusion of middle cerbral artery is sign of major strokes and affects these regions | frontal, parietal and temporal lobes
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conditions caused by occlusion of the middle cerebral artery | aphasia in dominant hemisphere, contralateral hemiplegia
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occlusion of posterior cerebral artery impacts what regions | diencephalon, temporal and occipital lobes
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conditions caused by occlusion of posterior cerebral artery | visual & sensory loss, contralateral hemiplegia if cerebral peduncles
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how do we measure cerebral blood flow | MAP between 50-150 mmHg. if below 50, we have diminished flow. Above 150 indicates hyperemic increased blood flow, risk of bleed
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What can cause increased ICP | tumor, head injury, increased CSF or blood
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BBB formed by | astrocytes and junctions between endothelial cells of capillaries
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What transport mechanism used to transport across BBB | active pumps used
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Clinical procedures for drug admin across BBB | ventriculostomy, intrathecal, lumbar pump
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in terms of energy mobilization, symp and psym--> | sympathetic mobilizes energy, parasympathetic conserves energy
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