Peripheral NS Receptors
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| Cholinergic Receptor Subtypes | Nicotinic N, Nicotinic M, Muscarinic | (blank)
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| Nicotinic N | All autonomic NS ganglia and adrenal medulla | Stimulation of parasympathetic and sympathetic nerves and release of epinephrine from the adrenal medulla
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| Nicotinic M | Neuromuscular junction | Contraction of skeletal muscle
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| Muscarinic 1a/8 | Eye - the ciliary muscle | Contraction of the ciliary muscle focuses the lens for near vision
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| Muscarinic 1b/8 | Eye - the iris sphincter muscle | Contraction of the iris sphincter muscle causes miosis (decreased pupil diameter)
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| Muscarinic 2/8 | Heart | Decreased HR
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| Muscarinic 3a/8 | Lung - bronchi | Constriction of the bronchi
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| Muscarinic 3b/8 | Lung | Promotion of secretion
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| Muscarinic 4a/8 | Bladder - detrusor (smooth muscle of the bladder wall) | Contraction of detrusor increases bladder pressure
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| Muscarinic 4b/8 | Bladder - trigone and sphincter | Relaxation of trigone and sphincter allows urine to leave the bladder.
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| what causes voiding of the bladder? | Coordinated contraction of detrusor and relaxation of trigone and sphincter. - response to what reseptor? | Muscarinic
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| Muscarinic 5/8 | GI tract 1/4 | Salivation
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| Muscarinic 5/8 | GI tract 2/4 | Increased gastric secretions
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| Muscarinic 5/8 | GI tract 3/4 | Increased intestinal tone and motility
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| Muscarinic 5/8 | GI tract 4/4 | Defecation
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| Muscarinic 6/8 | Sweat glands | Generalized sweating
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| Muscarinic 7/8 | Sex organs | Erection
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| Muscarinic 8/8 | Blood vessels | Vasodilation
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| activation of nicotinic N (neuronal) receptors promotes (where, what)? | at all ganglia of the sympathetic and parasympathetic NS and also at the adrenal medulla | ganglionic transmission (from the former) and epinephrine release (from the latter)
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| Activation of muscarinic receptors (which are located on) 1-3/6 | the target organs of the parasympathetic NS (causes what?) | 1) incresed glandular secretions (from pulmonary, gastric,intestinal, and sweat glands). 2) contraction of the smooth muscle in the bronchi and GI tract; 3) slowing of HR;
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| Activation of muscarinic receptors (which are located on) 4-6/6 | the target organs of the parasympathetic NS (causes what?) | 4)contraction of the sphincter muscle of the iris (miosis); 5) contraction of the ciliary muscle of the eye (lens to focus for near vision); 6) voiding of the urinary bladder (contraction of the detrusor and relaxation of trigone and sphincter muscles)
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