Y2- NMB Unit Pharm MOA
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| Phenytoin (Dilantin) | Selectively binds to inactivate Na+ channels and decrease Glutamate release from excitatory presynaptic neurons.
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| Carbamazapine | Stabilizes the inactivated state of Na+ channels. Potentiate GABA receptors.
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| Lamotrigine | Blocks voltage gated Na+ channels. Decrease release of Glutamate from excitatory NTs
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| Valproic acid | Increase Na+ channel inactivation. Inhibits GABA transaminase
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| Gabapentin | Binds to presynaptic N-type Ca++ channels. Decrease NT Release
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| Topiramate | Block voltage gated Na+ channels. Antagonize AMPA/kainate glutamate receptors.
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| Phenobarbital | Bind GABAa receptor and prolong duration of CL- channel opening
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| Ethosuximide | Blocks thalamic T-type Ca++ channels.
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| Lorazepam (Benzo) Diazepam | bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening.
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| Short Acting (highest addiction potential) triazolam, oxazepam, alprazolam, midazolam | bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening. Fix OD with Flumenazil
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| Medium Acting estazolam, lorazepam, temazepam | bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening. Fix OD with Flumenazil
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| Long Acting (greatest fall risk) chlordiazepoxide, diazepam, flurazepam, clonazepam, clorazepate | bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening. Fix OD with Flumenazil
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| Tigabine | Selective GABA reuptake inhibitor
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| Vigabatrin | Irreversibly inhibit GABA transaminase
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| Levetiracetam | Inhibit voltage dependent N=type Ca++ channels. Bind to synaptic proteins that modulate neurotransmitter release.
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| Oxycarbazepine | Na+ channel blocker
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| Felbamate | Has an effect on GABA receptor binding sites
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| Lacosamide | Enhance slow activation of Na+ channels and interacts with CRMP-2
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| Rufinamide | Prolongs the inactivation state of the Na+ channel
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| Sulthiame | Carbonic anhydrase inhibitor
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| Zonisamide | Binds Na+ channels, Voltage sensitive Ca++ channels, partial CAI
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