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a&p II test 2

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Question
Answer
what is the cardiovascular system composed of?   a pump (heart), a conducting system(blood vessels), a fluid medium(blood),  
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functions of blood   distribution, regulation, and protection  
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what does blood distribute   O2 and nutrients to body cells, metabolic waste to lungs and kidneys, and hormones to endocrine organs  
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what does blood regulate?   body temperature, pH, and fluid volume in the circulatory system  
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what does bllod protect against   blood loss, and infection  
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what does whole blood contain   plasma and the formed elements  
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what is plasma made of?   92% water, 7% plasma protiens, 1% other solutes  
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what are the formed elements   erythrocytes (rbc) and leukocytes (wbc) and platelets  
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what is the cardiovascular system composed of?   a pump (heart), a conducting system(blood vessels), a fluid medium(blood),  
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what are the physical characteristics of blood?   opaque fluid, scarlet or dark red, pH 7.35-7.45, 38C, 8% of body weight average volume is 5-6L for men and 4-5L for females  
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functions of blood   distribution, regulation, and protection  
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what are the plasma protiens?   albumins 60%, globumins 35%, and fibrinogen 4%  
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what does blood distribute   O2 and nutrients to body cells, metabolic waste to lungs and kidneys, and hormones to endocrine organs  
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what are albumins   transport substances such as fatty acids, thyroid hormones, and steroid hormones  
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what does blood regulate?   body temperature, pH, and fluid volume in the circulatory system  
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what are globumins   antibodies, also called immunoglobumins. transport globumins: hormone binding protiens and steriod binding protiens  
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what does bllod protect against   blood loss, and infection  
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what are fibrinogen   molecules that form clots and produce long, insoluble strands of fibrin  
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what does whole blood contain   plasma and the formed elements  
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what is serum?   liquid part of blood sample, in which disolved fibrinogen has converted to solid fibrin  
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what is plasma made of?   92% water, 7% plasma protiens, 1% other solutes  
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what are the formed elements   erythrocytes (rbc) and leukocytes (wbc) and platelets  
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what are the physical characteristics of blood?   opaque fluid, scarlet or dark red, pH 7.35-7.45, 38C, 8% of body weight average volume is 5-6L for men and 4-5L for females  
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what are the plasma protiens?   albumins 60%, globumins 35%, and fibrinogen 4%  
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what are albumins   transport substances such as fatty acids, thyroid hormones, and steroid hormones  
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what are globumins   antibodies, also called immunoglobumins. transport globumins: hormone binding protiens and steriod binding protiens  
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what are fibrinogen   molecules that form clots and produce long, insoluble strands of fibrin  
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what is serum?   liquid part of blood sample, in which disolved fibrinogen has converted to solid fibrin  
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what is hemoglobin   the red pigment in whole blood hat gives it its color. binds and transports oxygen and carbon dioxide  
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what is the structure of RBC   small highly specialized discs, thin in the middle and thick around the edges  
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what is the function of RBC   dedicated to respiratory gas exchange  
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what are the important aspects of the structure   high surface to volume ratio allows quick absorption and release of oxygen, discs can stack in roileaux to smooth the floow through narrow blood vessels, and the descis bend and flex so they can enter small capillaries  
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what is the lifespan of an RBC   120 days, they lack a nuclei, mitochondria and ribosomes so there is no repairs  
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what is the structure of hemoglobin?   has two alpha and two beta chains each has a heme pigment bonded to it. each heme has an iron atom which can bind to one oxygen molecule so each hemoglobin molecule can transport four oxygen  
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what is the function of hemoglobin   carries oxygen and transports carbon dioxide back to the lungs  
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how are RBCs recycled and broke down   marcrophages of liver, spleen and bone marrow engulf RBC before it ruptures, hemoglobin is broke down by phagocytes into biliverdin, biliverdin is converted to bilirubin which is secreted by the liver  
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erythropoiesis   occures in myeliod tissue (red bone marrow) in adults. stem cells mature to RBCs  
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the stages of maturation for RBCs   is myeloid stem cell, proerythroblast, erythroblasts, reticulocyte, and mature RBC  
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regulation of erythropoiesis   balance between too few and too many RBCs depends on hormone controls and supplies of amino acids, iron, and B vitamins  
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what arethe four types of blood   a ,b, ab, o  
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the RH factor   your blood can be RH+ or RH-  
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what happens in a cross reaction   plasma antibodies meet specific surface antigen, blood agglutinates and hemolyze  
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white blood cells   called leukocytes, do not have hemoglobin, have nuclei and other organelles  
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functions of WBCs   defend against pathogens, remove toxins and waste, and attack abnormal cells  
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types of WBCs   granulocytes (neutrophils,esoinophils, and basophils) monocytes, and lymphocytes  
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neutrophils   50-70% of circulating WBCs. first to attack bacteria, angulf and digest pathogense, release prostglandins and leukotrienes and form pus  
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esinophils   2-4% of WBCs, attack large paracites, excrete toxi compounds, sensitive to allergens, control inflammation  
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basophils   less than 1% of WBCs , accumulate in damaged tissue, release histamine and heparin  
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monocytes   2-8 % of WBCs, larger than RBCs, migrate in and out of blood, ,ostly found in connective tissues and lymphoid organs, part of bodoies specific defence system  
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platelets   cell fragments involved in human clotting system,circulate for 9-12 days, are removed by spleen, 2/3 are reserved for emergencys  
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functions of platelets   release important clotting chemicals, temporarily patch damaged vessel walls, and reduce the size of break in vessel walls  
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platelet production   occures in bone marrow (thrombocytopoiesis) megakaryocytes manufacture plateles from cytoplasma.  
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three stages of homeostasis   vascular phase, platelet phase, and coagulation phase.  
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vascular phase   a cut triggers vascular spams that last 30 minutes (3 stages)  
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stage one of vascular phase   Endothelial cells contract and expose basement membrane to bloodstream  
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stage two of vascular phase   Endothelial cells Release chemical factors ADP, tissue factor, and prostacyclin, Release local hormones, endothelins, Stimulate smooth muscle contraction and cell division  
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stage three of vascular phase   Endothelial plasma membranes become “sticky” Seal off blood flow  
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platelet phase   Begins within 15 seconds after injury: platelet adhesion and platelet aggregation  
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platelet adhesion   To sticky endothelial surfaces, To basement membranes, To exposed collagen fibers  
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platelet aggregation   Forms platelet plug which closes small breaks  
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factors that limit growth of platelet plug   Prostacyclin, released by endothelial cells, inhibits platelet aggregation, Inhibitory compounds released by other WBCs, Circulating enzymes break down ADP, Negative (inhibitory) feedback from serotonin, Development of blood clot isolates area  
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coagulation phase   Begins 30 seconds or more after the injury: Cascade reactions: Chain reactions of enzymes and proenzymes, Form three pathways, Convert circulating fibrinogen into insoluble fibrin  
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three coagulation pathways   extrinsic pathway, intrinsic pathway, and common pathway  
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extrinsic pathway   Begins in the vessel wall, Outside bloodstream, Damaged cells release tissue factor (TF), TF + other compounds = enzyme complex, Activates Factor X  
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intrinsic pathway   Begins with circulating proenzymes, Within bloodstream, Activation of enzymes by collagen, Platelets release factors (e.g., PF-3), Series of reactions activates Factor X  
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common pathway   Where intrinsic and extrinsic pathways converge, Forms enzyme prothrombinase, Converts prothrombin to thrombin, Thrombin converts fibrinogen to fibrin  
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clot reaction   Pulls torn edges of vessel closer together Reducing residual bleeding and stabilizing injury site, Reduces size of damaged area Making it easier for fibrocytes, smooth muscle cells, and endothelial cells to complete repairs  
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fibrinolysis   Slow process of dissolving clot: Thrombin and tissue plasminogen activator (t-PA), Activate plasminogen, Plasminogen produces plasmin and Digests fibrin strands  
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anticoagulants   antithrombin-III, heparin, aspirin, protien C, and prostacyclin  
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what does the pulmonary circuit do?   carries blood to and from gas exchange surfaces of lungs  
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what does the systemic circuit do?   carries blood to and from the body  
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what are the three types of blood vessels?   arteries, veins, and capillaries  
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arteries   carry blood away from the heart  
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veins   carry blood to the heart  
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capillaries   form networks between arteries and veins. and carry blood to the cardiac muscles.  
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what are capillaries also called?   exchange vessels because they exchange materials between blood and tissues  
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four chambers of the heart?   right atrium, right ventricle, left atrium, and left ventricle.  
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right atrium   collects blood from systemic surface  
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right ventricle   pumps blood to pulmonary circuit  
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left atrium   collects blood from pulmonary circuit  
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left ventricle   pumps blood to systemic surface  
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the heart   it is located slightly left of the midline. it is composed of great veins and arteries at the base, the pointed tip is called the apex, it is surrounded by a pericardial sac, and it sits between two pleural cavities in the mediastinum  
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the pericardium   a double lining of the pericardial cavity, the two linings are visceral and parietal  
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the visceral pericardium   inner layer of pericardium  
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the parietal pericardium   outter layer of pericardium  
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pericardial cavity   between the visceral and parietal layers and contains a pericardial fluid  
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paricaditis   inflammation of the paricardial sac  
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atria   thin walled, and has an expandable sac called an auricle  
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coronary sulcus   divides the atria and ventricles  
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anterior and posterior interventricular sulcus   separates left and right ventricles, contains blood vessels of cardiac muscles  
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what three layers makes up the heart wall?   epicardium, myocardium, and endocardium  
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epicardium (outer layer)   visceral pericardium, covers the heart  
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myocardium (middle layer)   muscular wall of the heart, concentric layer of cardiac muscle tissue, atrial myocarium wraps around great vessels  
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endocardium (inner layer)   simple squamous epithelium  
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intercalated disc   interconnect cardiac muscle cells, secured by desmosomes, linked by gap junctions, convey force of contraction, and propogate action potentials  
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characteristics of cardiac muscle cells   small size, single central nucleus, branching interconnections between cells, intercalated discs  
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interatrial septum   separates atria  
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interventricular septum   separates ventricles  
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atrioventricular (AV) valves   connect atrium to ventricles, they are folds of fibrous tissue that extended into openings between atria and ventricles,blood presssure closes cusps during ventricular contraction permit blood flow in one dirrection  
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right atrium   contains superior vena cava, inferior vena cava, coronary sinus, and foramen ovale, and pectinate muscles.  
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superior vena cava   recieves blood flow from head, neck, upper limbs, and chest  
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inferior vena cava   recieves blood from trunk, viscera, and lower limbs  
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coronary sinus   cardiac veins return blood to coronary sinus, coronary sinus opens into right atrium  
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foramen ovale   efore birth is an opening through interatrial septum, connects two atria. seals off at birth forming fossa ovalis  
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pectinate atrium   contain prominent muscular ridges, located on atrial wall and inner surfaces of right auricle  
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right ventricle   free edges attach to chordea tenineae from papillary muscles of ventricle, prevent valve from opening backward.  
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right atrioventricular (AV) valve   also called tricuspid valve, opening from right atrium to right ventricle, has three cusps, prevents backflow  
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trabeculae carneae   muscular ridges on internal surfaces of right and left ventricle, includes moderator band, ridge contains part of conducting system, coordinates contraction of cardiac muscle cells  
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pulmonary circuit   superior end of right ventricle leads to pulmonary trunk, pulmonary trunk divides into left and right pulmonary arteries, blood flows from right ventricle to pulmonary trunk through pulmonary valve, pulmonary valve has three semilubar cusps  
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left atrium   blood gathers into left and right pulmonary veins, pulmonary veins deliver to left atrium, blood from left atrium passes to left ventricle through left AV valve (bicuspid pr mitral valve)  
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left ventricle   holds same volume as right ventricle, is larger, muscle is thicker and more powerful, similar internally to right ventricle bu no moderater band  
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systemic circulation   blood leaves left ventricle through aortic valve into ascending aorta, acending aorta turns (aortic arch) and becomes descending aorta  
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semilunar valves   pulmonary and aortic tricuspid valves, prevent backflow from pulmonary trunk aorta into ventricle, have no muscular support  
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aortic sinuses   at base of ascending aorta, sacs that prevent valve cusps from sticking to aorta, origin of right and left coronary arteries  
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cardiac skeleton   four bands around heart valves and bases of pulmonary trunk and aorta, stabilize valves, electrically insulate ventricular cells from atrial cells  
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coronary circulation   cupplies blood to muscle tissue of heart, coronary arteries and cardiac veins  
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coronary arteries   left and right, originate at aortic sinuses, high blood pressure, elastic rebound forces blood through coronary arteries between contractions  
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right coronary artery   supplies blood to right atrium, portions of both ventricles, cells of SA and AV nodes, marginal arteries, and posterior interventricular artery  
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left coronary artery   supplies blood to left ventricle, left atrium, and interventricular septum.  
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what are the two main branches of left coronary artery?   circumflex artery, and anterior interventricular artery  
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cardiac veins   great cardiac veins, anterior cardiac veins, posterior cardiac vein, middle cardiac vein, and small cardiac vein  
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great cardiac vein   Drains blood from area of anterior interventricular artery into coronary sinus  
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anterior cardiac veins   Empty into right atrium  
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posterior cardiac vein, middle cardiac vein, and small cardiac vein   Empty into great cardiac vein or coronary sinus  
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coronary heart disease (CAD)   Areas of partial or complete blockage of coronary circulation, Reduction in blood flow to heart muscle produces a corresponding reduction in cardiac performance  
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coronary ischemia   reduced circulartory supply. results from partial or complete blockage of coronary artereis  
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causes of CAD   formation of a fatty deposit (atherosclerotic plaque) in the wall of coronary vessel, The plaque or an associated thrombus then narrows the passageway and reduces blood flow, Spasms in smooth muscles of vessel wall can further decrease or stop blood flow  
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angina pectoris   its most common form is a temporary ischemia which develops when the workload of the heart increases, can feel comforatble at reast but exertion or emotional stress can produce sensation of pressure  
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myocardial infarction (MI) (heart attack)   Part of the coronary circulation becomes blocked, and cardiac muscle cells die from lack of oxygen, The death of affected tissue creates a nonfunctional area known as an infarct,most commonly result from severe coronary artery disease (CAD)  
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consequences of a MI   near start of coronary artery: damage will be widespread and hear may stop beating, if involves one of smaller arterial branches: person may survive immediate crisis by may have complications like reduced contractility & cardiac arrythmias  
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treatment of CAD   Stop smoking, High blood pressure treatment , Dietary modification to lower cholesterol and promote weight loss, Stress reduction, Increased physical activity (where appropriate)  
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drug treatment of CAD   Drugs that reduce coagulation and therefore the risk of thrombosis, such as aspirin and coumadin, Drugs that block sympathetic stimulation, Drugs that cause vasodilation, such as nitroglycerin,  
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noninvasive surgery to treat CAD and MI   atherectomy, balloon angioplasty, or coronary srtery bypass surgery  
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atherectomy   Blockage by a single, soft plaque may be reduced with the aid of a long, slender catheter inserted into a coronary artery to the plaque  
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balloon angioplasty   The tip of the catheter contains an inflatable balloon, Once in position, the balloon is inflated, pressing the plaque against the vessel walls Because plaques commonly redevelop after angioplasty,a stent may be inserted into the vessel, holding it open  
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coronary artery bypass surgery   a small section is removed from either a small artery or a peripheral vein and is used to create a detour around the obstructed portion of a coronary artery,As many as four coronary arteries can be rerouted this way during a single operation  
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cardiac physiology   conducting system control and coordinate heartbeat and contractile cells produce contractions that propel blood  
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cardiac cycle   Begins with action potential at SA node: Transmitted through conducting system, Produces action potentials in cardiac muscle cells (contractile cells)  
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conducting system   A system of specialized cardiac muscle cells Initiates and distributes electrical impulses that stimulate contraction  
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structures of the conducting system   Sinoatrial (SA) node - wall of right atrium, Atrioventricular (AV) node - junction between atria and ventricles, Conducting cells - throughout myocardium  
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conducting cells   Interconnect SA and AV nodes, Distribute stimulus through myocardium, In the atrium: Internodal pathways, In the ventricles: AV bundle and the bundle branches  
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prepotential   Also called pacemaker potential, Resting potential of conducting cells Gradually depolarizes toward threshold, SA node depolarizes first, establishing heart rate  
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heart rate   SA node generates 80–100 action potentials per minute, Parasympathetic stimulation slows heart rate, AV node generates 40–60 action potentials per minute  
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sinoatrial (SA) node   In posterior wall of right atrium, Contains pacemaker cells, Connected to AV node by internodal pathways, Begins atrial activation (Step 1)  
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atrioventricular (AV) node   In floor of right atrium, Receives impulse from SA node (Step 2), Delays impulse (Step 3), Atrial contraction begins  
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AV Bundle   In the septum, Carries impulse to left and right bundle branches Which conduct to Purkinje fibers (Step 4), And to the moderator band Which conducts to papillary muscles  
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pukinje fibers   Distribute impulse through ventricles (Step 5), Atrial contraction is completed, Ventricular contraction begins  
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abnormal pacemaker function   bradycardia, tachycardia, etopic pacemaker  
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bradycardia   abnormally slow heart rate  
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tachycardia   abnormally fast heart rate  
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etopic pacemaker   Abnormal cells , Generate high rate of action potentials, Bypass conducting system Disrupt ventricular contractions  
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electrocardiogram   A recording of electrical events in the heart, Obtained by electrodes at specific body locations, Abnormal patterns diagnose damage  
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features of an ECG   p wave, QRS complex, T wave  
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P Wave   atria depolarize  
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QRS complex   ventricle depolarize  
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T Wave   ventricles repolarize  
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time intervals between ECG Waves   P-R inerval, Q-T interval  
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P-R interval   From start of atrial depolarization, To start of QRS complex  
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Q-T interval   From ventricular depolarization, To ventricular repolarization  
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contractile cells   Purkinje fibers distribute the stimulus to the contractile cells, which make up most of the muscle cells in the heart  
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refractory period   Absolute refractory period: Long , Cardiac muscle cells cannot respond; Relative refractory period: Short, Response depends on degree of stimulus  
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role of calcium ions in cardiac contraction   Contraction of a cardiac muscle cell Is produced by an increase in calcium ion concentration around myofibrils  
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stages of calcium ions in cardiac contractions   Calcium ions enter plasma membrane during plateau phase, Arrival of extracellular Ca2+ Triggers release of calcium ion reserves from sarcoplasmic reticulum As slow calcium channels close Intracellular Ca2+ is absorbed by the SR Or pumped out of cell  
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cardiac cycle   Is the period between the start of one heartbeat and the beginning of the next , Includes both contraction and relaxation  
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phases of cardiac cycle   systole (contraction), diastole (relaxation) atrial systole, ventricular systole, atrial diastole, ventricular diastole  
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atrial systole   atrial contraction begins and right and left AV valves are open, atria eject blood into ventricles filling them, atrial systole ends AV valves close, ventricles have max bloo volume. known as end-diastolic volume (EDV)  
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venticular systole   ventricles contract and build pressure, pressure exceeds vessel pressure opening the semilunar valves allowing the blood to leave ventricle, amnt of blood ejected is called stroke volume (SV), pressure falls and semilunar valves close end systolic volume  
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ventricular diastole   ventricular pressure is higher than atrial pressure, all heart valves are closed, ventricles relax, atrial pressure is higer than ventricular pressure, AV valves open, passice atrial filling, passive ventricular filling  
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blood pressure   Rises during systole, Falls during diastole Blood flows from high to low pressure Controlled by timing of contractions and Directed by one-way valves  
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heart sounds   S1: loud sounds produced by AV valves, S2: loud sounds produced by semilunar valves, S3 and S4: soft sounds produces by blood flow into ventricles and atrial contraction  
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heart murmur   sounds produced by regurgitation through valves  
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cardiac output   the volume pumped by left ventricle in one minute  
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factors effects cardiac output   heart rate: adjusted by autonomic nervous system or hormones, stroke volume adjusted by changing EDV or ESV  
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effects on the SA node   Membrane potential of pacemaker cells is Lower than other cardiac cells, Rate of spontaneous depolarization depends on: Resting membrane potential or Rate of depolarization  
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sympathetic and parasympathetic stimulation   gratest at SA node (heart rate)  
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ACh   slows heart rate  
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NE   speeds heart rate  
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atrial reflex   Also called Bainbridge reflex, Adjusts heart rate in response to venous return, Stretch receptors in right atrium Trigger increase in heart rate Through increased sympathetic activity  
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factors effecting the strok volume   The EDV amount of blood a ventricle contains at the end of diastole, filling time, and venous return  
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the EDV and stroke volume at rest   EDV is low, Myocardium stretches less, Stroke volume is low  
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EDV and stroke volume with exercise   EDV increases, Myocardium stretches more, Stroke volume increases  
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Frank-Starling principle   As EDV increases, stroke volume increases Physical Limits: Ventricular expansion is limited by: Myocardial connective tissue, The cardiac (fibrous) skeleton, The pericardial sac  
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end systolic volume   Is the amount of blood that remains in the ventricle at the end of ventricular systole  
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three factors that effect ESV   Preload: Ventricular stretching during diastole, Contractility: Force produced during contraction, at a given preload, Afterload: Tension the ventricle produces to open the semilunar valve and eject blood  
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