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Bakhtar-Male Reproductive Pathology

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seminoma   most common pure germ cell tumor identical to dysgerminoma gray-white lobulated cut surface large round cells, clear cytoplasm, large nuclei, prominent nucleoli in dense background of lymphocytes secrete hCG  
spermatocytic seminoma   germ cell tumor unrelated to "classic" seminoma no metastatic potential three cell types: medium, small, giant  
embryonal carcinoma   germ cell tumor can be aggressive often hemorrhagic undifferentiated cells growing in alveolar or tubular pattern  
yolk sac tumor   germ cell tumor counterpart of endodermal sinus tumor in females most common testicular tumor in children < 3 y.o. Schiller Duval Bodies Secrete AFP  
choriocarcinoma   germ cell tumor highly malignant tumor hemorrhagic and necrotic syncytiotrophoblasts (secrete hCG) and cytotrophoblasts  
teratoma   germ cell tumor benign and/or malignant components from more than one germ cell layer can have mature/immature elements can have respiratory elements differentiated teratomas in males: -children: benign -post-pubertal: malignant  
leydig cell tumor   sex cord tumor secretes androgens  
lymphoma   most common testicular tumor in patients > 60 y.o. most common is diffuse large B-cell lymphoma  
mixed tumor   germ cell tumor most common testicular tumor prognosis worsens based on type of cancer  
seminoma vs non-seminoma   seminoma: often present at low age, primarily lymphatic route of spread, radiosensitive non-seminoma: often present at high age, primarily hematogenous route of spread, radioresistant  
cryptochordism   failure of intra-abdominal testis to descend two phases: transabdominal and inguinosacral (the most common) 75% unilateral increased risk of cancer in both testes  
hypospadias   congenital defect urethral opening on underside of penis  
epispadias   congenital defect urethral opening on topside or bottom side of penis  
phimosis   foreskin can't be retracted fully over glans penis  
testicular torsion   twisting of spermatic cord venous drainage blocked and increased arterial pressure-->hemorrhagic infarct testis remain viable if untwisted within 6hrs underlying malignancy should always be excluded  
condyloma   skin disease HPV-related dysplasia: HPV 6 and 11 display koilocytic atypia  


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Created by: kphom001 on 2011-11-14

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