Ch. 29, Pharm
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| what are the two forms of lipids in the blood | triglycerides and cholesterol
🗑
|
||||
| what are apolipoproteins | specialized lipid carrying proteins
🗑
|
||||
| what is lipoprotein | combo of triglyderides or cholesterol with apolipoprotein
🗑
|
||||
| what are the types of lipoproteins | VLDL- very low density lipoproteins
LDL- low density
HDL- high density
🗑
|
||||
| what does HDL do | recycle cholesterol and is the good cholesterol
🗑
|
||||
| what level of cholesterol makes someone risk for CHD | >300mg/dl 3-4x greater than <200mg/dl
🗑
|
||||
| What are positive risk factors for CHD | male 45+, female 55+, family hx, smoker, BP 140/90+, HDL <40
🗑
|
||||
| what are negative risk factors (beneficial) | high HDL >60
🗑
|
||||
| What do antilipemic drugs do | lower lipid levels, adjunct to diet therapy
🗑
|
||||
| how long should non-drug means of lowering lipid levels be attempted before drug therapy | 6 months and then fail
🗑
|
||||
| What are the classes of antilipemics (6) | HMG-CoA reductase inhibitors(HMGs or statins)
bile acid sequestrants
Niacin
Fibric acid derivitives (fibrates)
Cholesterol absorption inhibitor (Zetia)
Combination drugs (Vytorin)
🗑
|
||||
| How do HMGs or statin reduce lipids | inhibit HMG-CoA reductase which is used by liver to produce cholesterol, block liver from producing cholesterol, first line drugs
🗑
|
||||
| What is an adverse affect for statins | myopathy, muscle pain which can lead to rhabdomyolysis(destroyed muscle cells)
🗑
|
||||
| What are the bile acid sequestrants | cholestyramine(Questran)
colestipol hydrocholoride(Colestid)
colesevelam(tablet form)
🗑
|
||||
| how do bile acids sequestrants work | bile acids are necessary for absorption of cholesterol, they gather up bile and prevent reabsorption of bile acids from sm. intestine
🗑
|
||||
| Bile acids reduce cholesterol how | natural way liver excretes cholesterol, the more bile acids excreted in feces, more the liver converts cholesterol to bile acids. reduces chol. in liver
🗑
|
||||
| What are the indications of bile acids | mgmt of type II hyperlipoproteinemia and alongside statins
🗑
|
||||
| what are adverse affects of bile acid sequestrants | constipation, heartburn, N, bleching, bloating
🗑
|
||||
| What vitamin is Niacin | vitamin B3, need lg doses to lower cholesterol
🗑
|
||||
| how is niacin affective in lowering cholesterol | lowers triglycerides, total serum cholesterol and LDL levels and incr HDL.
Reduce metabolism/catabolism of triglycerides and cholesterol
🗑
|
||||
| what are adverse affects of niacin | flushing, pruritis, GI distress, can take NSAIDs 30 min before, take weeks to work
🗑
|
||||
| What are two fibric acid derivatives | gemfibrozil(Lopid), fenofibrate(Tricor)
🗑
|
||||
| what is the mechanism of action for fibric acid derivatives | decr triglycerides, incr HDL 25%, suppress release of free fatty acids from adipose
🗑
|
||||
| what are adverse affects of fibric acid derivatives | blurred vision..."fiber in your eyes", constipation esp. Clofibrate so incr fiber in diet
🗑
|
||||
| What is a cholesterol absorption inhibitor | Zetia
🗑
|
||||
| what are some herbal products that help lower cholesterol | garlic, flax, Omega 3, interactions with Warfarin
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
palmerag
Popular Pharmacology sets