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Regulation of Blood Pressure

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Question
Answer
What is the major cardiovascular variable being regulated?   Mean arterial blood pressure.  
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Why is this important to regulate?   Because it is the driving force for blood flow to organs  
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What regulates mean arterial blood pressure?   Stroke volume  
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How do you calculate MAP?   Cardiac output x total peripheral resistance  
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What is TPR?   Net resistance of all organs in body  
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BARORECEPTORS: What are the two kinds that exist?   BARORECEPTORS; arterial and cardiopulmonary baroreceptors.  
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Where are the arterial baroreceptors located?   Two carotid sinuses and aeortic arch.  
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What are arterial baroreceptors?   Nerve endings that are sensitive to stretch due to changes in arterial blood pressure  
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What do they do with the change?   Buffer changes in arterial blood pressure  
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What happens to wall of blood vessel and firing of AP when blood pressure is increased?   Increased wall blood vessel --> Increase AP  
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What happens if you decrease pressure?   Increase resistance and heart rate  
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What does the firing rates of arterial baroreceptors directly depend on?   MAP and pulse pressure  
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What sort of feedback is associated with baroreceptors?   negative feedback  
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CARDIOPULMONARY BARORECEPTORS?   CARDIOPULMONARY BARORECEPTORS  
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Where are they located?   Large systemic veins, pulmonary vessels, and the walls of the heart.  
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What is their function?   Keep the brain informed of changes; Do the same as the other baroreceptors; They sense changes in stuff.  
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What sort of feedback don't they use? What kind of pressure do they measure?   Don't use negative feedback. venous pressure  
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What does an increase in ABp lead to?   Increase AP of arterial baroreceptors  
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What does afferent info do when stimulated?   Goes up to cardiovascular center in medulla.  
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What do efferent nerves do when stimulated?   Increase parasympathetic outflow and decrease sympathetic outflow.  
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The parasympathetic outflow goes to....? And the sympathetic outflow doesn't go to?   Heart, arterioles, and veins  
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What is the result of the increase in arterial blood pressure?   Decrease CO, TPR, and MAP  
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What is the arteriole baroreceptor reflex?   Does the opposite of the above; i.e. decreases arterial blood pressure.  
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What is hte primary function of the baroreflex?   Shoprt term regulation of arterial blood pressure  
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BLOOD VOLUME AND LONG-TERM REGULATION OF ARTERIAL PRESSURE   LONG-TERM REGULATION OF ARTERIAL PRESSURE  
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Why can't baroreceptors set longo-term arterial pressure?   Because they can adapt or reset to changes in arterial bp  
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Thus, what does regulate arterial pressure in the long-term?   Volume, baby!  
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What happens to blood pressure when blood volume increases?   BP goes up  
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Why does this happen?   You increase venous return, E-D-V, SV, and C.O.  
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The increase in blood volume will then become what? Becuase of what?   Will then become a decrease in blood volume b/c kidneys extrete salt and water  
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What sort of feedback is this?   negative feedback loop  
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HEMORRHAGE AND HYPOTENSION   HEMORRHAGE AND HYPOTENSION  
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Define Hypotension: What can cause hypotension?   Low blood pressure; can be b/c of blood loss due to hemorhage.  
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What two mechanisms do we do to get over the hyipotension/   Reflex cardiovascular adjustments, and moving IF to capillaries  
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REFLEX CARDIOVASCULAR ADJUSTMENTS   REFLEX CARDIO  
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What do we increase in this case?   HR and TPR  
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What do we decrease (due to the bloo loss, not on purpose)?   Stroke volume, Cardiac output, and MAP  
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MOVEMENT OF IF TO CAPILLARIES   MOVE IF TO CAPS  
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What does this result in? (FINAL FINAL, imoprtant term)?   Hemodilution  
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What is whole blood?   Cells and plasma  
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What happens when you move IF to capillaries?   ??????  
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What are you essentially doing in the capillary movment thing?   Decrease Ventricular pressure and atrial pressure to decrease impact of hemorhage  
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What, other than hemorhage can cause hypotension?   Loss of body fluids, strong emotion, vasodilation chemcials  
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What is shock?   Low blood flow to tissues; damages them  
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UPRIGHT POSTURE   UPRIGHT POSTURE  
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What is the effect of gravity upon blood? How?   Reduce venous return by increasing vascular pressures in veins and capillaries in limbs  
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What happens when we stand up?   Blood-->veins-->legs-->decrease stroke volume-->decrease cardiac output  
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What does the increased venous pressure cause?   Distends veins and increases capilalry pressure-->increases filtration out of capillaries  
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When are these effects minimized?   Skeletal muscle contraction in legs  
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EXCERCISE   EXCERCISE  
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Why does CO increase in excercise?   HR and stroke volume increases  
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What is redistribution?   When the increase in cardiac output goes to vasodialating skeletal muscles and away from internal organs and nonactive skeleatl muscle  
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So how do we get blood to active muscles? Away from non-active muscles and ogans?   Vasodialation; vasoconstriction  
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REGULATION   REGULATION  
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What three things happen during excercise?   Vasodilation, constriction, and increase HR  
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Why does vasodilation happen in excerciese?   Active hyperemia  
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Why does vasoconstriction happen?   SNS activity to internal organs and non-active muscles  
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Why does increase HR happen in excercise?   Decrease parasympathetic and increased sympathetic activity  
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TRAINING   TRAINING  
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What is the maximal oxygen consumption? What the only way to change it?   Max oxygen use level; doesn't increase normally  
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Training:   Increase max stroke volume and cardiac output by increasing oxygen consumption  
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HYPERTENSION   HYPERTENSION  
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Why does hypertension happen?   Increased TPR from increased arteriolar constriction  
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What is the most common hpertension type? What happens there? Why?   Primary hypertension; caused by increased arteriolar constriction; we don't know why they increase  
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HEART FAILURE   HEART FAILURE  
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HWhen does heart failure occur?   Decreased contractility --> Not enough CO  
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What does an increase in diastolic volume do to systolic volume?   Increases it  
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What does heart failure lead to?   Makes kidneys retain fluid and increases capillary pressure  
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What does the capillary pressure increase lead to?   edema and filtration  
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What does edema at the ankle mean?   Right heart failure  
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What does pulmonary edema mean?   Left ventricle failure  
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CORONARY ARTERY DISEASE   CORONARY ARTERY DISEASE  
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Infarction:   Complete coronary artery block  
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What can cause acute death from a heart attack?   V-fib  
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