lecture 9 dowell
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| vincristine's unique properties | NON-emetogenic and NON-myelosuppressive
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| dexamethasone action | directly lympholytic
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| time frame for rescue with leucovorin | < 36 hrs
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| brain is a sanctuary site for mets | many chemotherapy agents don't achieve adequate levels in the CNS
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| dose dense tx | giving the same amt of drug but over a shorter period of time /// advantages: less time for tumor repopulation, disadvantages: much increased risk for toxicity
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| why leucovorin potentiates effect of 5-FU | ternary complex of 5-FdUMP, thymidylate synthase and methylene tetrahydrofolate is needed to stop purine synthesis. with more folate in the cell, more enzyme can be inhibited by 5-FU
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| pt develops acute myocarditis, ventricular tachy and resultant sz after chemo, suspect which drug? | doxorubicin (anthracyclines) has known unique cardiomyopathy side effect
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| secondary leukemia has been described after exposure to? | alkylating agents, epipodophyllotoxins and anthracyclines
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