Antibacterial compounds
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| ANTIBIOTICS CLASSIFIED ACCORDING TO THEIR BACTERIAL TARGETS | CLASSIFIED ACCORDING TO ANTI-BACTERIAL TARGET
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| What are CELL WALL SYNTHESIS INHIBITORS | Penicillins and cephalosporins
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| PENCILLINUS: | PENCILLINUS
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| What is it? | The original Beta lactum structure penicillin G
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| What does Pen G. look like? | The beta lactum strucuture with a ring and methyl group
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| What are penicillinase resistant forms?> | change in structure to make penicillin active
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| What is an examle of one? And what doees it work on? | Methicillin (oxacillin)—Works on gram + orgs
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| What are some penicillinase inhibitors? | Clavulanic acid and augmentin
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| Which is used more often/ | Gluvanic acid b/c it is cheaper
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| Cephalosporins | CEPHALOSPORINS
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| Why do we need to use generations of ceophalosproins? | B/c bugs become resistant
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| How do cephalosporins work? | You don't kill the bacteria, you just create wall in cell
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| What cell type do they work against? | Gram + and negative
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| What is the final generation in which you can kill an infection/ | 4th generation
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| PROTEIN SYNTHESIS INHIBITORS | PROTEIN SYNTHESIS INHIBITORS
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| Why are Aminoglycosides good? | Active b/c bact ribosomes are different
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| What is an example of such a drug? On which organism does it work? | Streptomycin--effective on lots o' stuff
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| Chlorophenicol: | FIG. 20.10 ID
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| What does erythro do to the translation process? Where does it bind? | Erythro prevents move of ribosome along mRNA by bidning to the 30s portion.
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| FIG. 20.12 | We try to make them more active
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| Nucleic acid synthesis inhibitors: | SYNTHESIS INHIBITORS
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| What do they do? Example of one? | We make amino acid; Rifamycins
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| METABOLIC INHIBITORS | METABOLIC INHIBITORS
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| Whare are some of them/ | Sulfa drugs, and TMPSMZ
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| WHAT IS AN AWESOME DRUG REGARDING MIC AND ALL THAT? | Streptomycin, DUDE!!
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| What does penicilin, cephalosporins do? | Inhibit cell wall synthesis
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| What does streptomycin, erythromycin do? | Inhibit protein synthesis
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| What does rifampin, quinolones do? | inhibit replication
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| What does TMZ-SMP do? | Block metabolsim, little enzyme like thing
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| SMP is what kind of inhibitor? Top or bottom of sequence? | competitive; top of sequence
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| TMP is what kind of inhibitor? Top or bottom? | competitve one (bottom os sequence)
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| In what three ways can a bacteria increase its resitance to a drug? | !) Enzymatic destruction of the drug 2) Lack of entry into cell 3) Change drug target
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| What are the two types of anti-fungal drugs we need to know? | Cotrimazole, microtonozole
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