10-3
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| EPO levels in Polycythemia Vera? | low (high would imply theres hypoxia...which there isnt)
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| what do you give for refractory pruritis in PV? | IFN-a
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| What Ig's are increased in multiple myeloma? What cell types are incrased? | IgG, IgA (IgM is Waldenstrom's Macroglobulinemia). Cell type= plasma cell
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| Bence Jones proteins are found in the urine of which dz? | Multiple Myeloma. B-J proteins = kappa/gamma light chains
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| What do serum protein levels look like in MM | total proteins are raised, but albumin is normal (IgG/IgA cause the protein increase)
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| HL age, and unique cell type? Most common type? | age = bimodal (young and elderly). unique cell= Reed Sternberg ((o)(o)). common type of HL= nodular sclerosing
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| Starry sky appearance is what dz? what chromosomal abnormality is present? | Burkitt Lymphoma (a type of NHL)..due to EBV infxn. t8;14
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| Chemo therapy in HL can lead to ________ | secondary malignancy in breast/lung
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| Leukemia common in Downs? | ALL
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| what cell type precursors are present in ALL | B cell
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| myoloperoxidase postive blasts are found in ________ | AML (duh, myeloid cells stain with MYELOperoxidase)
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| a-naphthylesterase+ implies ? | M5 variant of AML
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| smudge cells are found in ________ | CLL
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| Chromosomal abn in CML? | 9;22
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| What type of leukemia has blast crisis? | CML
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| drug used to treat CML? | imatinib (tyrosine kinase inh, since BCR-ABL is tyrosine kinase gene)
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| TRAP+ stain is in _______ | hairy cell leukemia
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| tumor lysis causes __K+, ____Ca, ____PO4, ______uric acid | all raised except Ca (it binds the PO4)
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| Rx for anorexia caused by cancer? | Megestrol Acetate (progesterone derivative)
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| difference in cell's involved btwn Fanconi Anemia and Diamond Blackfan (both have a shitload of congenital malformations) | FA= all blood cells involved (hypocellular bone marrow). DBF= only RBCs
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