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Day 12

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
        Help!  

Question
Answer
What is the MC brain tumor?   Metastases  
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What are the 3 MC primary brain tumors in adults?   Glioblastoma multiforme, Meningioma, and Schwannoma  
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What are the 3 MC primary brain tumors in children?   Astrocytoma, Medulloblastoma, and Ependymoma  
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Which primary brain tumor fits the following description?: pseudopalisading necrosis   Glioblastoma multiforme  
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Which primary brain tumor fits the following description?: polycythemia   Hemangioblastoma  
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Which primary brain tumor fits the following description?: Neurofibromatosis type II   Schwannoma (to remember which neurofibromatosis syndrome, just think of wearing II earrings b/c you have II ears)  
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Which primary brain tumor fits the following description?: a/w von Hippel-Lindau syndrome   Hemangioblastoma  
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Which primary brain tumor fits the following description?: foamy cells, high vascularity   Hemangioblastoma  
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Which primary brain tumor fits the following description?: Prolactinemia--> galactorrhea, amenorrhea, anovulation   Prolactinoma (pituitary adenoma)  
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Which primary brain tumor fits the following description?: Psammoma bodies   Meningioma  
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Which primary brain tumor fits the following description?: Fried egg appearance   Oligodendroglioma  
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Which primary brain tumor fits the following description?: Perivascular pseudorosettes   Ependymoma  
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Which primary brain tumor fits the following description?: Bitemporal hemianopia   Pituitary adenoma and craniopharyngioma (in kids)  
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Which primary brain tumor fits the following description?: worst prognosis of any primary brain tumor   Glioblastoma multiforme  
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Which primary brain tumor fits the following description?: Child with hydrocephalus   Ependymoma and medulloblastoma  
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Which primary brain tumor fits the following description?: Homer-Wright pseudorosettes   Medulloblastoma  
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Which seizure is this: localized and specific area of brain?   Partial  
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Which seizure is this: no alteration of consciousness?   Simple  
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Which seizure is this: Altered consciousness?   Complex  
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Which seizure is this: affects entire brain?   Generalized  
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What are the MCC of seizures in children?   Genetic, infection (febrile), trauma, congenital, and metabolic  
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What is the classic "Charcot's triad" seen in MS?   Scanning speech, intention tremor, and nystagmus  
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Name that headache!: aura, nausea and vomiting, photophobia, phonophobia, lasts 24-48 hours   Migraine  
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Having an aura with a migraine prevents patients from taking what popular prescription drugs?   OCPs  
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Name that headache!: unilateral, can last 30min to several hours, relieved with oxygen administration, may have Horner's-type symptoms (ptosis, miosis), and rhinorrhea on ipsilateral side   Cluster headaches  
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Name that headache!: bilateral steady pain lasting more than 30min, not aggravated by light or noise, no aura   Tension headache  
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What allele is assoc'd with Alzheimer's disease?   APP on chromosome 21= early onset; Apo E4 allele on chromo 19= late onset (Apo E2 on chromo 19 is protective against Alzheimer's)  
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Why is Alzheimer's so common in patients with Down syndrome?   B/c the APP gene is located on chromosome 21, and Down patients have 3 copies of this chromosome.  
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A woman presents with headache, visual disturbance, and amenorrhea. What is the diagnosis?   Pituitary adenoma  
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A 43 yo man presents with symptoms of dizziness and tinnitus. CT shows enlarged internal acoustic meatus. What is the diagnosis?   Acoustic Schwannoma  
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A child exhibits proximal m weakness and enlarged calves. What is the disease, and how is it inherited?   DMD; X-linked (X-linked diseases: Fabry's Tale: Duchenne the Muscular HUNTER BRUTally Lysed the Albino Gopher without being aWAre it was a FRAGILE Hemophiliac)  
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A 25yo female presents with sudden uniocular vision loss and slightly slurred speech. She has a history of weakness and paresthesias that have resolved. What is the diagnosis?   Multiple Sclerosis  
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A 10yo child spaces out in class (stops talking mid-sentence) and then continues as if nothing had happened. During the spells, there is slight quivering of lips. What is the diagnosis?   Absence seizure  
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A patient presents with vertigo + tinnitus + hearing loss. What is the diagnosis?   Meniere's disease  
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Which endogenous agonist matches the following opioid receptor?: dynorphin   Kappa  
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Which endogenous agonist matches the following opioid receptor?: morphine   Mu  
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Which endogenous agonist matches the following opioid receptor?: enkephalin   Delta  
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Which medication fits the following description?: opioid cough suppressant   Dextromethorphan  
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Which medication fits the following description?: opioid used in the treatment of diarrhea   Loperamide and diphenoxylate  
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Which medication fits the following description?: opioid commonly used in the treatment of acute heart failure   Morphine (LMNOP: Loop diuretics like furosemide, Morphine, Nitrates, Oxygen, Pressors/Positioning)  
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Which medication fits the following description?: opioid receptor antagonist   Naloxone, naltrexone  
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Which medication fits the following description?: non-addictive weak opioid agonist   Tramadol  
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Which medication fits the following description?: partial opioid agonist that causes less respiratory depression   Butorphanol  
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What 5 drug classes are used to treat glaucoma?   Alpha agonists, beta blockers, diuretics (mannitol, acetazolamide), cholinomimetics, and prostaglandins (-prost drugs)  
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What drugs are known for causing Steven's Johnson syndrome?   Sulfa drugs, seizure drugs, -cillins, and allopurinol  
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How is barbiturate overdose managed?   Symptomatically  
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How is benzo overdose managed?   Flumazenil  
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Which anesthetic fits the following description?: IV a/w hallucinations and bad dreams   Ketamine  
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Which anesthetic fits the following description?: inhaled, SE nephrotoxic   Methoxyflurane (methoxy is nephrotoxy! yeah baby!)  
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Which anesthetic fits the following description?: IV , MC drug used for endoscopy   Midazolam (+ an opioid like fentanyl)  
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Which anesthetic fits the following description?: inhaled, SE convulsions/seizures   Enflurane  
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Which anesthetic fits the following description?: inhaled, SE hepatotoxic   Halothane  
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Which anesthetic fits the following description?: IV, used for rapid anesthesia induction and short procedures   Propofol  
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Which anesthetic fits the following description?: inhaled, used for rapid anesthesia   nitric oxide  
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Which anesthetic fits the following description?: IV, decreases cerebral blood flow (important in brain surgery)   BARBIturates like thiopental (BARBIe is dumb b/c she has decreased cerebral blood flow)  
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Which anesthetic fits the following description?: IV, does not induce histamine release like morphine   Fentanyl  
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Which anesthetic fits the following description?: high triglyceride content increases risk of pancreatitis with long-term use   Propofol  
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What agents are used in the treatment of Parkinson's disease?   Bromocriptine, Amantadine, L-Dopa + carbidopa, Selegiline, Antimuscarinics (Benztropine)= BALSA  
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What side effects are common to most all of the anti-epileptics?   Diplopia, sedation, ataxia, nystagmus, and dizziness  
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What are the toxic SE of phenytoin?   Hirsuitism, gingival hyperplasia, fetal hydantoin syndrome, drug-induced lupus, SJS, and CYP-450 induction  
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What is the mechanism of action of dantrolene?   Blocks Ca release from the sarcoplasmic reticulum  
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What is the mechanism of action of local anesthetics?   Block Na channels  
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Which n fibers are blocked first with local anesthesia?   Small myelinated fibers (small myelinated first-> small unmyelinated-> large myelinated-> large unmyelinated last)  
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What drug can be used to reverse the neuromuscular blockade?   Neostigmine is the prototype drug  
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What is the mechanism of action of the drugs used in the treatment of Alzheimer's disease?   Memantine is an NMDA receptor ANTAGonist (helps prevent excitotoxicity; mediated by Ca) and donezepil, galantamine, and rivastigmine are all AChE inhibitors (problem with AD is that they don't have enough ACh).  
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What is the mechanism of action of sumatriptan?   Serotonin 1B/1D receptor agonist that causes vasoconstriction (headaches are caused by vasodilation; think of blood filling up spaces in the brain causing pressure and pain)  
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For what populations is sumatriptan contraindicated?   Pregnant women, people with CAD, and people with Prinzmetal's angina  
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