Pharmocology-Autonomics1.0/adrenergic receptor agonists
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| What are Catecholamines? | Direct acting agents
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| What drugs are catacholamines? | NE, EPI, DA (direct or indirect), Dobutamine
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| NE works on what receptors? | alpha, beta1
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| EPI works on what receptors? | alpha, beta1, beta2
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| ISO works on what receptors? | beta1, beta2
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| DA works on what receptors? | beta1, renal D1, dose related
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| dobutamine works on what receptors? | beta1selective, alpha1, beta2
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| What are noncatacholamines? | direct acting agents
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| What drugs are noncatacholamines? | Phenylephrine, methoxamine, Isoetherine, Metaproterenol, Terbutaline, Fenoterol, Albuterol, Pirbuterol
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| Phenylephrine and methoxamine works at what receptors? | alpha
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| Isoetherine, Metaproterenol, Terbutaline, Fenoterol, Albuterol, and Pirbuterol works at what receptors? | beta2, metaproterenol most potent
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| what are Indirect acting agonists? | reserpine and cocaine
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| pretreat with cocaine, what is the response to direct agonist? indirect agonist? | increased/decreased
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| pretreat reserpine, what is the response to direct agonist? indirect agonist? | increased/decreased
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| agent for cardiac arrest/life support? | EPI
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| cardiogenic or septic shock? | continuous infusion of dobutamine, DA, EPI or NE
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| agent for CHF? | dobutamine, DA (beta1)
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| agent for allergic reactions? | EPI or other beta agonists
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| agent for local vascular effects? | EPI, cocaine (prolong duration of anastetic)
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| agent priapism? | alpha agonist local injection into penis
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| agent for nasal decongestant? | alpha1 agonist
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| agent for athsma? | beta agonist
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| agent to inhibit preterm labor? | selective beta2 agonists
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| agent for HTN? | central alpha2 agonist (clonidine)
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| pharmacologic use for EPI? | bronchodialator, rapid allergic relief, prolong local anasthetic, restore cardiac rythm, vasopressor, hemostatic agent, glaucoma
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| pharmacologic use for NE? | hypotension, increase PVR in shock
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| action and receptor for amphetamine dextroampetamine? | indirect, alpha and beta
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| pharmacologic use for amphetamine dextroampetamine? | obesity, narcolepsy, ADHD
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| action/receptor/pharmacologic use for cocaine? | indirect, alpha and beta, topical hemostatic and local anasthetic
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| action/receptor/pharmacologic use for ephedrine? | indirect and direct, alpha and beta, narcolepsy and obesity
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| pharmacologic use for ISO? | emergancy heart block or bradycardia, pacemaker
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| pharmacologic use for dobutamine? | acute HF, CHF, postop or postMI
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| pharmacologic use for DA? | shock, hypotension, CHF, increase urine output (dopa vs beta receptor effect)
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| pharmacologic use for metoproternol? | bronchodialator used in athsma
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| pharmacologic effects of terbutaline? | bronchodialator and uterine relaxation
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| pharmacologic effects of ritodrine? | uterine relaxation
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| pharmacologic effects of albuterol? | bronchodialator used in athsma
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| pharmacologic effects of phenylephrine? | mydriatic for retina exam, cardiothoracic surgury, nasal decongestant
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| pharmacologic effects of methoxamine? | hypotension, PSVT (vagal effect)
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| pharmacologic effects of metaraminol? | hypotension, PSVT (vagal effect)
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| pharmacologic effects of pseudoephedrine? | nasal decongestant
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| pharmacologic effects of clonidine? | antihypertensive agent, withdrawal symptoms, analgesic
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| pharmacologic effects of apraclonidine and brimonidine? | opthalmic drops used in glaucoma
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| pharmacologic effects of guanfacine, guanabenz and methyldopa? | antihypertensive agents
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