USMLE 2CK - Tumor Markers
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| PSA | Prostate-specific antigen. Used to screen for prostate carcinoma.
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| Prostatic acid phosphatase | Prostate carcinoma.
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| CEA | Carcinoembryonic antigen. Very nonspecific but produced by approx. 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas.
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| α-fetoprotein | Normally made by fetus. Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis (yolk sac tumor). Ovarian endodermal sinus tumors and embryonal carcinoma.
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| β-hCG | Hydatidiform moles, choriocarcinomas, and gestational trophoblastic tumors. Ovarian germ cell tumor (embryonal carcinoma).
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| CA-125 | Ovarian, malignant EPITHELIAL tumors.
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| S-100 | Melanoma, neural tumors, astrocytomas.
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| Alkaline phosphatase | Metastases to bone, obstructive biliary disease, Paget’s disease of bone.
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| Bombesin | Neuroblastoma, lung and gastric cancer.
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| TRAP | Tartrate-resistant acid phosphatase. Hairy cell leukemia––a B-cell neoplasm.
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| CA-19-9 | Pancreatic adenocarcinoma.
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| LDH | Dysgerminoma (germ cell) tumors of the ovary.
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| Inhibin | Granulosa (stromal) cell tumor of the ovary.
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| Estrogen | Granulosa (stromal) cell tumor of the ovary. Can cause endometrial hyperplasia → diffuse uterine enlargement.
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