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Gastroenterology

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Answer
Colon cancer risk:   doubles each decade after 40 yo; M>F; 90% occur after 50; sig higher risk if 1st-degree relative with colon ca  
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Colon cancer Genl RFs   Age; Personal hx colon polyps or ca; FH; inherited syndromes; T2DM; IBD  
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Colon cancer lifestyle RFs   Diet (red meat); physical inactivity; obesity; smoking; heavy alcohol use  
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2 types of dx criteria for HNPCC   Amsterdam; Bethesda  
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S/S colon cancer   Rectal bleeding; Fe def anemia; Fatigue / wt loss; obstruction (left sided tumors); change in stool quality/caliber; abdominal mass or abd pain  
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Colon cancer: most common metastases are to:   liver, then lung (colon); liver or lung (rectal ca)  
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Colon cancer: gold standard of dx eval:   colonoscopy  
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Colon cancer: other dx eval   CT with contrast abd/pelvis (for staging). CXR. Needle bx of suspected mets. PET scan only for suspected mets dz  
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Colon cancer: labs   CBC, chemistry; may check CEA, but not for dx (help w/staging)  
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Cancer stage is determined from:   PE, biopsy, imaging, lymph node dissection  
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Layers of colon wall   Mucosa; muscularis mucosa; submucosa; muscularis propia; subserosa/serosa  
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Types of ablation of mets   Radiofrequency Ablation; Ethanol ablation; Cryosurgery; Hepatic artery embolization  
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Goal of chemo:   Eradicate micrometastasis to increase likelihood of cure; none for stage 0 or I; resected stage II: poss modest survival benefit but not routinely recommended  
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Indications for radiation tx in colorectal cancer   not typically used for colon cancer. Used for rectal cancer  
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Screening: stool Tests:   primarily detect cancer; Guaiac FOBT & immunochemical-based FIT; Stool DNA (sDNA)  
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Screening: Structural Exams:   Detect cancer and polyps; Colonoscopy; CT colonography; Flexible Sigmoidoscopy; Double-contrast barium enema (uncommon)  
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Best mortality data for CRC screening:   Guiac FOBT  
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Never screen for colon ca with:   DRE  
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Positive FOBT should always be followed by:   colonoscopy (and no more FOBTs needed)  
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Negative FOBT tests should be:   repeated annually  
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Flexible Sigmoidoscopy procedure description   Examines left colon; some bowel prep needed; can be performed w/o sedation in Dr’s office. 5-year interval between exams  
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Patients w/ adenomas found on flex sig should:   have a colonoscopy  
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Colonoscopy: procedure description   Direct inspection of entire colon with sedation (usu conscious); thorough bowel prep required  
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Colonoscopy false negative rates   6-12% miss rates for large adenomas; 5% miss rates for cancer  
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Most common serious complication of colonoscopy   bleeding post-polypectomy; Perforation = 1/1000 and increases with age and diverticular disease  
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Colon cancer screening   FOBT at age 50-75 yrs (alt: colonoscopy or sigmoidoscopy). USPSTF: no screen for >75 y.o.  
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Colon cancer surveillance   once ca/adenomatous polyps are detected, occurs at shorter intervals (usually repeat colonoscopy in 3-5 years); If FH CRC: every 5 yr; IBD: yearly once disease present for more than 15 yr  
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Colon polyps (types)   adenomatous (poss pre-malig: req shorter surveillance colonoscopy interval); hyperplastic (not considered pre-malig)  
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CT colonography   No sedation; req bowel prep; pos result req f/u colonoscopy  
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Colon polyps: more likely to be malignant if:   sessile, >1cm, villous  
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Colon polyps: less likely to be malignant if:   pedunculated, <1cm, tubular  
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If 2 first-degree relatives have CRC or 1 relative with colon ca or adenomatous polyps:   Screen at 40 y.o. (or 10 yrs <earliest family dx)  
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Colon ca: most common metastases are to:   liver, then lung (colon); liver or lung (rectal ca)  
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