Anticoagulants/Platelets Inhibitors/Thrombolytic & Diuretec Drugs-kidney functio
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| Brand Name Coumadin | Generic Name warfarin sodium
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| Coumadin/Warfarin | Oral anticoagulation therapy. Blocks intrinsic pathway. Inhibity syntesis of Vit K. Prevents growth of formed clots.
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| Brand Name Heparin | Generic Name heparin
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| Heparin | Injectable anticoagulation therapy. Works immediately. Inhibits clots by blocking fiber production.
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| Brand Name Reopro | Generic Name abciximab
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| Reopre/abciximab | Biologic - few side effects. adjucnt to heparin.
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| -ab | Monoclonal antibody fragment works on platelets only
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| Brand Name Activase I.V. | Generic Name alteplase
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| Activase I.V/alteplase | Biologic. Single dose clot buster
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| -ase | enzyme
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| Brand Name Procrit | Generic Name epoetin alpha
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| Procrit means | Promote red blood cell production
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| Procrit/epoetin alpha | Hormone and also a biologic. Stimulates red blood cell production for anemia, cancer, chronic renal failure
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| Blood Clots | Thrombus
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| thrombus | stationary clot
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| embolus | circulating clot
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| thromboembolization | movement of clot
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| statis | stops blood and it pools in atrium.
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| atrial fibulation | quivering of atrial valve. irregular rhythm.
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| Intrinsic pathway | blood coming in contact with foreign object. cut on glass etc.
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| Extrinsic pathway | internal issue.
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| How clots form | RBC's get trapped in fiber structure and starts forming clots. Platelets which are smaller than RBC's stablalize the clots.
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| -mab | monoclonal antibody
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| -ase | enzyme
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| -lysis | break apart
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| fibrinolysis | breaks apart fiber
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| small molecule drugs | older, cheaper priced. synthasized by chemical reactions
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| large molecule drugs | Biologics - ex. vaccine. Proteins - synthasized by biological systems ex. cells. More expensive priced. Hard to reproduce generic. Much more complex.
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| Diuretics | increase urine production. Increase water loss. Used for edema and conjestive heart failure.
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| Furosemide | Loop diurectics. used in Loop of Henle. High capacity.
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| Thiazides | used in distal convoluted tubule
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| Spironolacton | potassium sparing diuretic used in collecting tubule
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| Nephron | structual unit of kidney. complex filter.
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| glomerulus | leaks out liquids (salts etc.)
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| Kidney does what? | recycles
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| How many different tubules in kidney? Name? | 5. Proximal convoluted tubule, Proximal straight tubule, Loop of Henle, Distal convoluted tubule, Collecting tubule.
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| Diuretic drug brand name Diaqua | Generic name hydrochlorothiazide HCTZ
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| -iazide | suffix for generic thiazide diuretics. they act on distal convoluted tubule.
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| Diuretic drugs treat what? | edema and hypertension
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| Diuretic drug brand name Lasix | generic name furosemide. Works in Loop of Henle.
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| Diuretic drug brand name Aldactone | generic name spironolactone. Works in collecting tubule. Potassium sparing diuretic.
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| Diuretic drug brand name Dyazide | generic name HCTZ/triamterene
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| Dyazide - HCTZ/triamterene | combination diuretic drug of Diaqua and Aldactone
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