MedMicro 2006 UTHSCmed
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| Bordetella pertussis Shape | small coccobacillus
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| Bordetella pertussis Aerobicity | Strict aerobe
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| Bordetella pertussis Oxidase +/-? | Osicase +
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| Bordetella pertussis fermenter | NON-fermenting
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| Bordetella pertussis Motility | NON-motile
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| Bordetella pertussis virulence factors | Adhesins, pertussis toxin: ADP-ribosylate, INC. cAMP; coordinated transcription of pathogenic genes
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| Bordetella pertussis Pathophysiology | Broplet nuclei; colonizes ciliated ceells, ciliostatsis: noninvasive; infects upper respiratory tract
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| Bordetella pertussis Diseases | Whooping cough (contagious in catarrhal stage)
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| Bordetella pertussis Specimen | Nasopharyngeal swab
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| Bordetella pertussis Lab Diagnosis | Chocolate agar, serology, immunofluorescence
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| Bordetella pertussis Treatment | Erythromycin (catarrhal or prophylactically), supportive treatment later
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| Bordetella pertussis Prevention/Control | DPaT vaccine (acellular)
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| Bordetella pertussis NOTES: | lymphocytosis; Incubation, catarrhal, paroxysmal, convalescent stages
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| B. parapertussis & bronchiseptica Shape | small coccobacillus
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| B. parapertussis & bronchiseptica Aerobicity | strict aerobe
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| B. parapertussis diseases | Mild pertussis
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| B. bronchiseptica diseases | respiratory disease (rare in humans)
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| Legionella pneumophila Shape | Pleomorph: bacillus to coccobacillus
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| Legionella pneumophila Aerobicity | Aerobic
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| Legionella pneumophila Catalase +/-? | Catalase +
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| Legionella pneumophila fermeter | NON-fermenting
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| Legionella pneumophila motility | Motile
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| Legionella pneumophila temperature | 0-63 C
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| Legionella pneumophila cirulence factors | Survive inside macrophages; proteolytic enzymes
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| Legionella pneumophila pathophysiology | Aerosolization, infects lower respiratory tract, causes intra-aveolar exudate of PMN's and macrophages
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| Legionella pneumophila reservoir | Water
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| Legionella pneumophila diseases | Legionnaire's disease (pneumonia, adnormal chest X-ray, bacteremia), Pontiac fever (normal chest x-ray)
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| Legionella pneumophila lab diagnosis | fastidious: requires L-cys for growth; gram stain, DFA, ELISA
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| Legionella pneumophila treatment | Axithromycin or levofloxacin (severe), erythromycin or tet (milder), no treatment for Pontiac fever (self-limiting)
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| Legionella pneumophila prevention/control | Hyperchlorination/treatment of water
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| Legionella pneumophila NOTES: | facultative intracellular pathogen, Legionnaire's disease has high mortality
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| Legionella pneumophila is a | ubiquitous aquatic saprophtyte
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| slender, Gram - aerobic bacilli | Legionella pneumophila
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| The two manifestations of Legionella pneumophila are | Legionnaire's disease and Pontiac fever
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| 2nd or 3rd most common cause of pneumonia | Legionella pneumophila
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| Bordetella stages:catarrhal | Resembles common cold; Purfuse mucoid rhinorrhea; malaise , fever, anorexia, sneezing. Most infectious stage
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| Bordetella stages: paroxysmal | convulsive coughing (w/whooping sound) for 2-4 wks up to 50 times a day often followed by vomitting
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| Bordetella stages: convalescent | gradual decrease in coughing and other symptoms. secondary complications: pneumonia, seizures, encephalopathy
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| Incubation period is 7 - 10 days | Whooping cough
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