MedMicro 2006 UTHSCmed
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| Yersinia pestis shape | Bacillus
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| Yersinia pestis Aerobicity | facultative anaerobe
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| Yersinia pestis fermenter? | YES it is a fermenter
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| Yersinia pestis motility | NON-motile
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| Yersinia pestis virulence factors | YOP proteins, capsule
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| Yersinia pestispathophysiology | Skin to bubo to bacteremia, lungs=pneumonic; septicemic
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| Yersinia pestis reservoir | Rats through fleas
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| Yersinia pestis diseases | Bubonic and pneumonic plague
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| Yersinia pestis specimen | Bubo aspirate, blood, sputum
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| Yersinia pestis lad diagnosis | Immunoflourescence
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| Yersinia pestis treatment | streptomycin, tetracycline, doxycline
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| Yersinia pestis prevention and control | rat control, pesticide, vaccine for high risk
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| Yersinia pestis | Kille 1/4 of europe, subcutaneous hemmorrhage="black death", facultative intracellular pathogen and sylvanic(rural) vs. urban (city) rodents
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| Francisella tularensis Shape | Coccobacillus
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| Francisella tularensis aerobicity | Facultative anaerobe
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| Francisella tularensis oxidase +/- ? | Oxidase +
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| Francisella tularensis fermenter? | NO
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| Francisella tularensis motility | NON-motile
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| Francisella tularensis virulence factors | penetrates unbroken skin; capsule, LPS (not very active)
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| Francisella tularensis Pathophysiology | skin to lymphatics to granuloma or pneumonia; ulcer at bite site; typhoid-like fever
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| Francisella tularensis reservoir | rodents and ticks or deer flies
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| Francisella tularensis specimen | sputum or exudate; skin test (rare)
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| Francisella tularensis diseases | tularemia (rabbit fever); ulceroglandular (bite); typhoidal (bad meat, rare), or pulmonary (rare)
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| Francisella tularensis lab diagnosis | serology
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| Francisella tularensis treatment | Streptomycin
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| Francisella tularensis prevention/control | gloves with animals, remove ticks, vaccine for high-risk
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| Francisella tularensis NOTES: | survives inside macrophages; seasonal incidence
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| Francisella tularensis NOTES: | facultative intracellular pathogen; typhoidal and pulmonary have high mortality
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| Brucella (melitensis, suis, abortus, canis) shape | Coccobacillus
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| Brucella (melitensis, suis, abortus, canis) aerobicity | facultative anaerobe
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| Brucella (melitensis, suis, abortus, canis) oxidase +/- ? | Oxidase +
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| Brucella (melitensis, suis, abortus, canis) fermenter? | NO
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| Brucella (melitensis, suis, abortus, canis) motility | NON-motile
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| Brucella (melitensis, suis, abortus, canis) virulence factors | LPS endotoxin
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| Brucella (melitensis, suis, abortus, canis) reservoir | goats and sheep (melitensis), suis (pigs), abortus (cattle)
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| Brucella (melitensis, suis, abortus, canis) diseases | brucellosis (undulating fever): acute (enteric illness), localized (in women), chronic, relapsing, or strain 19 (calf vaccine)
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| Brucella (melitensis, suis, abortus, canis) specimen | blood, bone marrow, incubate for 6 weeks
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| Brucella (melitensis, suis, abortus, canis) lab diagnosis | serology; culture on blood agar (slow, fastidious)
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| Brucella (melitensis, suis, abortus, canis) treatment | tetracycline + streptomycin for 3 weeks
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| Brucella (melitensis, suis, abortus, canis) prevention/control | no human vaccine in US; vaccinate cattle; minimize occupational exposure, pasteurize dairy products
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| Brucella (melitensis, suis, abortus, canis) NOTES: | Urease + , Facultative intracellular pathogen
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| Pneumonic Plague | very contagious and rapidly fatal.
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| Pneumonic plague can occur from: | metastic for bubo, Inhalation from infected person, direct inoculation of the lungs
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| Septicemic Plague | High mortality
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| Septicemic Plague occurs by: | Organisms inoculated directly into blood by flea.
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| Francisella tularensis (enteric) typhi-like fever | Hallmark feature is temp/heart rate dissociation
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| Francisella tularensis pulmonary | hallmark frothy bloody sputum like in pnuemonic plague
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