NUHS PHYS CH3
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cell containing a membrane-enclosed nucleus with genetic material; plant and animal cells | Eukaryotic cell
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Cells such as bacteria that do not contain their genetic info w/in a membrane-enclosed nucleus | Prokaryotic cell
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Membrane that forms outer surface of cell and separates cell's contents from extracellular fluid | Plasma membrane
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membrane bound compartment, along with some particles and filaments that perform specialized functions in cell | Cell Organelles
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large membrane bound organelle that contains cell's DNA; primary function is the storage & transmission of the genetic info to the next generation of cells | Nucleus
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region of cell interior outside of nucleus | Cytoplasm
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Intracellular fluid that surrounds cell organelles and nucleus | Cytosol
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performs a variety of functions, but most universal is to provide a selective barrier to the passage of molecules | Membranes
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major component of cell membranes; this lipid is a Amphipathic molecule | Phospholipids
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protein embedded in membrane lipid layer; may span entire membrane or be located at only one side | Integral membrane protein
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hydrophilic proteins associated w/ cytoplasmic surface in the interior of the membrane | Peripheral membrane proteins
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integral protein that spans the plasma membrane; often acts as a receptor or ion channel | Transmembrane protein
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transmembrane protein in plasma membrane; binds to specific proteins in extracellular matrix and on adjacent cells to help organize cells into tissues | Integrins
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junction that holds two cells together; consists of plasma membranes junction of adjacent cells linked by fibers. hold adjacent cells firmly together in areas that are subject to considerable stretching, such as skin | Desmosomes
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membrane junction in which extracellular surfaces of the plasma membrane of 2 adjacent cells are joined together so that no extracellular space remains between them and restricts molecule diffusion through space between cells | Tight junctions
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membrane junction that creates protein channels linking cytosol of adjacent cells; allows ions and small molecules to flow between cytosols of the connected cells | Gap junctions
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Double membrane surrounding cell nucleus | Nuclear envelope
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opening in nuclear envelope through which molecular messengers pass between nucleus and cytoplasm | Nuclear pores
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particular steroid (lipid) molecule which makes up 25% of cell membranes | Cholesterol
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fine network of threads made up of DNA & nuclear proteins; principal component of chromosomes | Chromatin
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highly coiled, condensed form of chromatin formed in cell nucleus during mitosis and meiosis forming rod like bodies | Chromosomes
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densely staining nuclear region containing portions of DNA that code for ribosomal proteins | Nucleolus
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cells which has no nucleus or organelles | Red blood cells
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cells which have multiple nuclei | Skeletal muscle cells
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protein factories of a cell; site of protein synthesis from amino acids, may be either free in cytosol or attached to endoplasmic reticulum | Ribosomes
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cell organelle that consists of interconnected network of membrane-bound branch tubules & flattened sacs; 2 types, rough; with ribosomes attached to synthesize protein, smooth; (no ribosomes attached) synthesizes lipids & detoxifies certain molecules | Endoplasmic reticulum
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cell organelle consisting of flattened membranous sacs; usually near nucleus; processes newly synthesized proteins for secretion or distribution to other organelles | Golgi apparatus
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membrane bound vesicle produced by Golgi apparatus; contain protein to be secreted by cell | Secretory vesicle
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cellular taxis that sorts & distributes vesicles | Endosomes
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oval shaped body surrounded by "2" membranes; site of production of most ATP during cellular respiration | Mitochondria
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cell organelle containing digestive enzymes in a highly acidic solution that break down bacteria, debris from dead cells, & or damaged cell organelles | Lysosomes
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cell organelle that makes or disposes of hydrogen peroxide | Peroxisome
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cytoplasmic filametous network which maintains the cell shape and provide cell movements; includes 3 types of protein filaments; microfilaments(actin), intermediate filaments, microtubules (cilia) | Cytoskeleton
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hairlike extension on epithelial cells to propel material along epithelial surface | Cilia
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unit of hereditary information; portion of DNA containing information req'd to determine a protein's amino acid sequence | Gene (20-25K genes in humans)
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complete set of an organism's genes | Genome
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Gene code is Universal, there are "3" Stop Codes, BUT only "1" Start Code | Universal genetic code for Methionine; A-U-G; "Start Code"
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any change in base sequence of DNA that changes genetic information | Mutation (3 types)
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the process of transferring genetic information from DNA to RNA in the nucleus | Transcription
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the process that used the coded information in RNA to assemble a protein in the cytoplasm | Translation
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ribonucleic acid that transfers genetic information for a protein's amino acid sequence from DNA to ribosome | Messenger RNA
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enzyme that forms RNA by joining together appropriate nucleotides after they have base-paired to DNA | RNA polymerase
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specific sequence of DNA nucleotide at the beginning of gene that controls the initiation of gene Transcription; determines which of the paired strands of DNA is transcribed into RNA template strand | Promoter
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small intracellular peptide that attaches to proteins and directs them to proteasomes | Ubiquitin
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a complex of proteins capable of denaturing (unfolding) other proteins and assisting in protein degradation | Proteasome
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initial portion of newly synthesized protein (if protein is destined for secretion out of the cell) | Signal sequence
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any molecule or ion that binds to protein surface by non covalent bonds (reversible) | Ligand
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region of a protein to which a specific ligand binds | Binding site
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selectivity; ability of binding site to react with only one, or limited # of molecules | Chemical Specificity
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strength with which ligand binds to its binding site (can be high or low) | Affinity
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refers to the fraction of total binding sites that are occupied by ligands at any given time | Saturation
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ability of similar molecules to combine with the same binding site or receptor | Competition
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alteration of a protein's shape, and therefore its function, by the covalent binding of various chemical groups to it | Covalent modulation (ex: Stereo's on/off switch)
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addition of phosphate group to an organic molecule | Phosphorylation
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any enzyme that phosphorylates other proteins by transferring to them a phosphate group from ATP | Protein kinase (ex: turns stereo on)
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any enzyme that removes phosphate from protein | Phosphoprotein phosphatase (ex: turns stereo off)
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control of protein binding site preoperties by modulator molecules that bind to regions of the protein other than the binding site altered by them | Allosteric modulation (ex: stereo's volume)
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ligand that, by action at an allosteric regulatory site, alters properties of other binding sites on a protein and thus regulates its functional activity | Modulator molecule
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site on protein that interacts with modulator molecule; alters functional site properties | Regulatory site
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binding site on allosteric protein that when activated, carries out protein's physiological function; also called active site | Functional site
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chemical reactions that occur in living organisms | Metabolism
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the synthesis of organic molecules by cells | Anabolism
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the breakdown of organic molecules by cells | Catabolism
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chemical reaction in which energy release is small enough for reverse reaction to occur readily | Reversible reaction
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chemical reaction that releases large quantities of energy and results in almost all reactant molecules being converted to product | Irreversible reaction
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maxim that an increase in reactant concentration causes a chemical reaction to proceed in direction of product formation | Law of mass action
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protein molecule, acts as protein catalyst that accelerates specific chemical reactions but does not itself undergo net chemical change during reaction | Enzyme (~2000 different enzymes in a typical cell)
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substance that binds to a specific region of an enzyme & is necessary for the enzyme's activity | Cofactor
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sequence of enzyme-mediated chemical reactions by which molecules are synthesized and broken down in cells | Metabolic pathway
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metabolic pathway that breaks down glucose to 2 molecules of pyruvate(aerobically, with O2) or 2 molecules of lactate (anaerobically, lack of O2) | Glycolysis
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mitochondrial metabolic pathway that utilizes fragments derived from carbs, proteins, and fat breakdown, & produces CO2, H, & small amounts of ATP | Krebs Cycle
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