Antibiotics
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| Penicillin | G+ BL-; syphilis, N.meningitidis; BL- N. gon
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| Ampicillin | Staph/Strep, Enterobactericiae (Ecoli/Proteus mirabilis); increasing G-
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| Amoxicillin | increasing G-, wimpy Enterobactericiae (Ecoli, P.mirabilis); Staph/Srep
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| Imipenem | zwitterion, smallest, gram - (requires calcium something addition)
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| Meropenem | zwitterion, smallest, gram -
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| Combos (Ticarcillin/Piper/Carbenicillin) | HI, Moraxella catarrhalis, Neisseria, Staph aureus
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| B lactamase inhibitor pairing combos | amox+clav; amp+sulbact
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| Nafcillin/Methicillin | gram +, staph/strep (no gram negatives)
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| First Gen Cephalosporins | CEPHALEXIN/CEFAZOLIN; B-lactamase + Staph (SSS-->staph/strep/surgeries) (no enterococci/no MRSA)
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| Sec Gen Ceph | cefuroxime; cefotetan; G- bacilli (enterobactericiae (no enterobacter/no pseudo)
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| Thrid Gen Cephalosporins | ceftazidime/cefotaxime/cefoperazone/ceftriaxone; pseudomonas, G-
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| Fourth Gen Cephalosporins | cefepime; pseudomonas G-
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| Aztreonnam | monobactam; G- aerobes, no anaerobes, no gram neg, no toxicity (like aminoglycosides without toxicity)
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| Vancomycin | gram positives; no gram positive meningitis (no BBB); MRSA; no VRE; no VRSA
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| What are the 2 macrolides | Erythromycin and Azithromycin
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| Erythromycin | Mycoplasma, Chlamydia, Legionella, Strep (substitute for penn); upsets stomach 50s
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| Azithromycin | 50s; mycoplasma, chlamydia, legionella, strep, HI, moraxella catarrhalis, Neisseria gon; emperic: sinusitus, otitis media, pneumonia 50s
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| Clindamycin | G+/G- anaerobes, MSSA, Streptococci, B frag; 50s (no enterococci; no g- aerobes)
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| Oxazolidanones | Linezolid 50s
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| Linezolid | 50s; VRSA; VRE; enterococcus facealis; good for resistant staph, enterococci, pneumococci
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| Tetracycline | 30s; tetra, mino, doxy; G+/G-; chlamydia, legionella, Rickettsia, Mycoplasma
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| Aminoglycosides | 30s; gentamicin, neomycin (topical), amikacin, tobramycin, streptomycin; aerobic G-, G+ w/pen (enterococci/enterobactericiae)
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| Chloramphenicol | chlamydia, ehrlichia, rickettsia, aplastic anemia (ER when Tetra won't work)
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| Quinolones | Cipro, Levofloxacin--DNA gyrase inhibitors (topoisomerase)
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| Cirpofloxacin | aerobes, FA, no anerobes, empiric CAP: Mycoplasma, M cat, chlamydia pneum, Legionella pneumophilia, Strep pnemo (no MRSA); MSSA, g- aerobes (oral pseudomonas)
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| oral pseudomonas | cipro
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| Metronidazole | synthetic; parasites (trich, giardia, entambeomeba; obligate anaerobes; (no propiones, no actinomyces); clostridium, pepto, bacteroides, porphrymonas, all tissues (brain ab, abd ab, C dif colitis) no aerobic (treat with second tx for anaerobic with metro)
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| Bactrim (TMP-SMX) | aerobes, no obligate anaerobes, protozoans; UTI, otitis media, pneumocystis pneumonia (fungal), travelers diarrhea, chronic bronchitis (acute exacerbations)
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| pneumocystis pneumonia | Bactrim
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| travler's diarrhea | bactrim
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| SMX inhibits what? | PABA analogue (synthetase)
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| TMP inhibits what? | DHF reductase
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