Catecholaminergic drugs part 1
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Vinca alcaloids (e.g. Vincristine), paclitaxel, colchicine | Block axonal transport of catecholamine NT's
🗑
|
||||
| Local anesthetics | Inhibit catecholaminergic neurotransmission
🗑
|
||||
| alpha-Methyl p-Tyrosine (Metyrosine, Demser (R)) | competitive inhibitor of tyrosine hydroxylase, treats pheochromacytoma
🗑
|
||||
| alpha-Methyldopa (Aldomet) | Inhibitor of L-aromatic amino acid decarboxylase, resulting product is a false transmitter, has agonist activity at alpha2 receptors, and thus antihypertensive activity
🗑
|
||||
| Disulfuram (Antabuse) | Inhibits acetaldehyde dehydrogenase, chelates copper cofactor in dopamine beta-hydroxylase, therefore can cause hypotension
🗑
|
||||
| Reserpine and other Rauwolfia alkaloids | Inhibit transport of dopamine and norepinephrine into the storage vesicles, may also affect storage of serotonin
🗑
|
||||
| Desperidine | Inhibits catecholamine storage
🗑
|
||||
| Guanethidine monosulfate (Ismelin Sulfate) | Inhibits catecholamine storage and prevents NT release, treats moderate to severe hypertension and renal hypertension
🗑
|
||||
| Guanadrel Sulfate (Hylorel) | Inhibits catecholamine storage, acts as a false NT, and prevents NT release, antihypertensive
🗑
|
||||
| Bretylium tosylate (Bretychol) | Inhibits catecholamine storage and prevents NT release, originally used as antihypertensive, now discontinued
🗑
|
||||
| Epinephrine (Primatine Mist, Bronkaid Mist), also HCl (Adrenalin) and Borate (Epinal) | Direct alpha and beta receptor agonist, treat bronchospasms, hypersensitivity reactions, prolong action of local anesthetics, restore cardiac rhythm during cardiac arrest
🗑
|
||||
| Norepinephrine bitartrate (Levophed) | Potent alpha agonist, little action on beta-2 receptors, used in treatment of some shock syndromes
🗑
|
||||
| Dipiverin hydrochloride (Propine) | Direct alpha and beta agonist, prodrug, used to treat open-angle glaucoma
🗑
|
||||
| Dobutamine hydrochloride (Dobutrex) | Direct alpha and beta agonist, has complex pharmacology, used clinically for cardiac stimulation
🗑
|
||||
| Phenylephrine hydrochloride (Neosynephrine) | Direct alpha agonist, used as a nasal decongestant and mydriatic (pupil dilation)
🗑
|
||||
| Metaraminol bitartrate (Aramine) | Direct alpha agonist, also indirect actions, treats hypotension
🗑
|
||||
| Methoxamine hydrochloride (Vasoxyl) | Direct alpha agonist, treats hypotension
🗑
|
||||
| Midorine hydrochloride (Proamatine) | Direct alpha-1 agonist, treats hypotension
🗑
|
||||
| Imidazolines (Xylometazoline, Oxymetazoline HCl, Naphazoline HCl, Tetrahydrozoline HCl) | Direct alpha-1 agonists, used as nasal and ocular decongestants, OTC
🗑
|
||||
| Clonidine (Catapres) | Centrally acting alpha-2 agonist, treats hypertension
🗑
|
||||
| Guanabenz Acetate (Wytensin) Guanfacine Hydrochloride (Tenex) | Analogues of clonidine, centrally acting alpha-2 agonists, treat hypertension, guanfacine-ADHD (off-label use)
🗑
|
||||
| Tizanidine Hydrochloride (Zanaflex) | Centrally acting alpha-2 agonist, used for muscle spasticity
🗑
|
||||
| Apraclonidine (Iodipine) | Alpha-2 agonist, reduces intraocular pressure
🗑
|
||||
| Brimonidine (Alphagan) | Analogue of apraclonidine, more selective for alpha-2 receptors, reduces intraocular pressure, can cause systemic side effects
🗑
|
||||
| Isoproterenol HCl (Isuprel) Isoproterenol sulfate (Medihaler-Iso) | Beta agonist, bronchodilator
🗑
|
||||
| Bitolerol mesylate (Ronalate) - metabolized to Colterol | Beta agonist, slight beta-2 selectivity, bronchodilator
🗑
|
||||
| Ethylnorepinephrine (Bronkephrin) | Beta agonist, little alpha agonist activity, bronchodilator
🗑
|
||||
| Isoetharine HCl (Arm-a-Med) | Beta agonist, more beta-2 activity, very little alpha activity, bronchodilator
🗑
|
||||
| Albuterol and Albuterol Sulfate (Proventil, Ventolin, etc.) | Beta-2 agonist, bronchodilator
🗑
|
||||
| Levalbuterol (Xopenex) | (R)-albuterol isomer, therapeautically active agent, beta-2 agonist, bronchodilator
🗑
|
||||
| Pirbuterol acetate (Maxair) | Beta-2 agonist, bronchodilator
🗑
|
||||
| Salmeterol xinafoate (Serevent) | Long-acting beta-2 agonist, used for long term management of bronchospasm
🗑
|
||||
| Formoterol fumarate (Foradil) | Long-acting beta-2 agonist, treats asthma, COPD, chronic bronchitis, and emphysema
🗑
|
||||
| Ritoridine HCl (Yutopar) | Beta-2 agonist, used to inhibit uterine contractions in preterm labor
🗑
|
||||
| Pseudoephedrine | Indirect acting adrenergic agonist, threo racemate of ephedrine
🗑
|
||||
| Dextroamphetamine sulfate (Dexedrine) | Indirect adrenergic agonist, readily crosses the blood-brain barrier, treats obesity and narcolepsy
🗑
|
||||
| Methamphetamine HCl (Desoxyn) | Indirect adrenergic agonist, previously used in treatment of ADD
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
100000197460889
Popular Medical sets