UCI SOM Smith
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| Hemopoietic tissue | bone marrow (myeloid tissue) and lymphoid tissue
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| Hemopoiesis | week 2-mesoblastic phase; month 2-hepato-splenic phase; end of 2nd trimester- myeloid phase starts and continues through life
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| When do leukocytes appear after conception | week 8
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| Stroma of marrow | 3D network of reticular/adventitial cells and reticular fibers in bone marrow
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| Parenchyma of marrow | divided into hematopoietic compartments responsible for the synthesis of erythrocytes and leukocytes
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| Hematopoietic cells | B and T lymphocytes, erythrocyte, megakaryocyte, monocyte, neutrophilic granulocyte, eosinophilic granulocyte, basophilic granulocyte
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| Erythropoiesis 5 steps | proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, orthochromatophilic erythroblast, reticulocyte
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| Proerythroblast | large, loose lacey chromatin, visible nucleoli, basophilic cytoplasm
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| Basophilic erythroblast | onset of Hb synthesis, strongly basophilic cytplasm, condensed nucleus, no nucleoli
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| Polychromatophilic erythroblast | cytoplasm filled with Hb, polyribosomes begin to decrease, final stage at which mitosis can occur
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| Orthochromatophilic erythroblast | cytoplasm filled with Hb, few polyribosomes, condensed nucleus, normoblast-late orthochromatophilic erythroblast
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| Reticulocyte | anucleate, most immature form released into circulating blood
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| Granulopoiesis 6 steps | myeloblast, promyelocyte, myelocyte, metamyelocyte, bend form, segmented neutrophil
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| Monopoiesis (3 stages) | monoblast (like a myeloblast), promonocyte (large, basophilic cytoplasm, lacy chromatin, slightly indented nucleus, last mitotic stage) and monocyte,
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| Lymphopoiesis | mostly occurs in thymus and peripheral lymphoid tissue but all lymphocyte progenitors come from bone marrow; lymphoblast -> prolymphocyte (smaller, condensed chromatin, lack surface antigens, migrate to lymphoid tissue)
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| Chronic leukemia | slow, proliferating cells are partly or completely differentiated
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| Acute leukemia | rapid progression, proliferating cells are undifferentiated precursur cells
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| Thrombocytopenia | reduction in platelet count; leukemia, metastatic cancer, chemotherapeutic drugs
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| Petichiea | purple pin pricks (thrombocytopenia purpura)
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| Echymoses | large breaks/bruises (thrombocytopenia purpura)
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