| Question |
 |
|
| Answer |
|
|
| If the breast is not expressing estrogen, but only progesterone, would you put someone on tamoxifen? |
no |
| What happens are 5 years of tamoxifen? |
tamoxifen switches and becomes a promoter for the estrogen receptor - acts as an agonist |
| What do you put patients on after tamoxifen? |
aromatase inhibitors - prevents conversion of androgen to estrogen |
| Describe the path from the ovary to the uterus |
fimbria, infundibulum, isthmus, ampulla, uterus |
| What are you trying to block with oral contraceptives? |
LH surge, prevent release of egg |
| Polycystic ovaries |
No LH surge - follicles all over ovary, high androgen level (from the adrenal) |
| DHEA from the adrenal |
high levels of DHEA (weak androgen) erase pulsatility of GnRH, critical for timing in cycles |
| How do you treat polycystic ovaries? |
hormone control of cycles |
| What will the level of FSH be in the post-menopausal female? |
increased - negative feedback from estrogen is gone |
| In a young boy diagnosed with precocious puberty, puberty is best delayed by administration of a long-lasting what? |
GnRH receptor agonist |
| Why give GnRH for precocious puberty? |
shuts down the male axis through giving high endogenous ligand, non-pulsatile - downregulat receptor |
5th Grade Science
