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Duke PA physiology

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Why do we need food?   Generate energy, aquire fuel substrates for energy reserves and provide raw materials for cell & tissue turnover and for heat loss  
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Body energy =   energy intake - energy output  
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Why do we need fuel?   maintain daily activities  
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Why do we need fuel reserves?   function between meals  
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Why do we need raw materials?   renew cells and tissues  
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What behavioral mechanisms govern when and how much food we eat?   hunger and satiety - governed by hormones  
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What is positive balance?   eating more food than using - gain weight  
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What is negative balance?   eating less food than we use - lose weight  
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What are the two ways to make ATP?   glycolysis and oxidative phosphorylation  
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How much ATP is made through glycolysis?   2 mol ATP + 2 pyruvate per glucose  
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How much ATP is made through oxidative phosphorylation?   34 mol ATP + CO2 + H20 per glucose  
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What is required for oxidative phosphorylation?   oxygen - only works under aerobic conditions  
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How is excess fuel from the diet stored?   glycogen, fat and protein  
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Which fuel storage contains the highest amount of energy stored?   fat  
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What is the most labile storage form?   glycogen  
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How much glucose per day is needed to maintain body at rest?   240g glucose  
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Respiratory quotient (RQ)   ratio of CO2 produced to O2 consumed  
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RQ for carb diet   1  
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What is the RQ of the brain?   very close to 1.0 - prefers carbs  
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What is the RQ of a mixed diet?   0.8  
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What is the RQ of an all fat diet?   0.7  
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How many kg of fuel are needed for a 100 kg body?   2300 kg fuel  
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BMR   basal metabolic rate  
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What does BMR depend on?   age, gender, amount of lean muscle mass, physical activity level, diet, hormones  
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What hormones dictate BMR?   thyroid, epi, norepi  
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What is the metabolic energy of proteins and carbs?   4 kcal/g  
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What is the metabolic energy of fat?   9 kcal/g  
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Which state is anabolic?   fed  
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Which state is catabolic?   fasting  
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Where can glycogen be stored?   liver and muscle  
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What is an anabolic state?   moving into storage  
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What is the dominant anabolic hormone?   insulin  
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Where is the glucose produced in a fasting state?   liver  
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What forms of energy does the liver produce in a fasting state?   ketones, glucose  
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What is a catabolic state?   breaking down stored fuel and breaking them down into fuel - glucose and ketones  
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What are the dominant catabolic hormones?   cortisol, epinephrine, glucagon  
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Where is excess energy store?   liver, muscle, fat  
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What control anabolic vs catabolic pathways?   hormones  
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What two hormones govern "minute to minute" maintenance?   insulin and glucagon  
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What four hormones work under stress?   cortisol, epinephrine, glucagon and growth hormone  
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What turns on stress hormones?   drop in glucose  
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What governs metabolism under long term starvation?   thyroid hormone  
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What does thyroid hormone do in starvation?   downregulated basal metabolic rate, conserve energy  
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When do plasma glucose levels rise?   after meals  
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What do plasma glucose levels do in sleep?   fall  
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What effect do a rise in plasma glucose levels have on insulin?   when glucose rises, insulin immediately goes up  
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What does glucagon do when insulin is up?   low glucagon  
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Does insulin or glucagon go through larger variations?   insulin - glucagon never jumps as much as insulin  
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How does the body regulate glucagon?   very tightly  
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Where does a stimulus go in increased plasma glucose levels?   stimulates release of insulin from beta cell  
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