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CV Pathology: Leech Lectures

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Question
Answer
What is the most common congenital heart malformation   ventricular septal defect  
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What is the second most common congenital heart malformation   atrial septal defect  
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True or False: Congenital heart disease is caused solely by genetic influence   False: Strong correlations exist between siblings, but enviornmental factors still come into play  
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Why is thalidomide important   known teratogen, causes congenital heart problems  
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When is the critcal window in development   3-8 weeks  
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Which type of shunt is more common L -> R or R -> L   L -> R  
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Which shunt would cause cyanosis and emboli from venous ciculation to enter systemic circulation   R -> L  
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What is the danger behind a L->R shunt becoming R->L   Signifigant pulmonary hypertension can develop and be IRREVERSIBEL  
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What are the number one cause of CHILDHOOD heart disease   shunts  
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What cardiac myopathy woudl cause digital clubbing and blood deficencies   Shunts  
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True or False: Obstructive myopathies usually cause cyanosis   FALSE  
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What are the three atrial septal defects in order of occurance   Secundum (Foreman ovale), Primum (Low in septum), Sinus Venosum (where SVC enters)  
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Which type of defect is usually silent until adulthood   Atrial Septal L-->R shunts  
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Ventricular septal defects are often associated with what other abonormality   tetralogy of Fallot  
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Where do 90% of ventricular septal defects occur   in the membranous material next to the aortic valve  
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True or False: 85-90% of PAD occurs as an isolated incident   true  
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What is a common presentation in a L-->R shunt that is finally picked up in adulthood   Right HEart failure or pulmonary hypertension  
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Which defect has a machine like sound to it   PDA  
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What are the requirements/components of Tetrolagy of Fallot   Ventircular septal defect. Overriding Aorta. Right ventricular Hypertrophy. Pulmonic Stenosis  
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What component of the Tetrology of Fallot determines severity   Pulmonary Stenosis  
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In Great Vessel transposition, what is the main determining factor of prognosis   How well the R. Ventricle can pump and whether there is sufficent PAD occuring  
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What myopathy occurs when the spiral ridges fail to decend   trunctus arteriosis  
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What always accompanies a trunctus arteriosus   Venticular septal defect  
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What malformation cuases one vessel to recieve blood from both ventricles   trunctus arteriosis  
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With which R-->L shunt disrder do you have r. ventricular hyoplasia and cyanosis from birth   Tricuspid Atresia  
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cardimegaly due to chronic pressure in the left ventricle can cause what   Coarctation of the aorta  
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Where do most coactations in the aorta take place   ust distal to the ductus or ligamentum arteriosus  
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When coarctation develops here, it is usually asymptomatic unless severe   postductal  
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Does collateral flow around a coarctation that is post ductal usually develop   yes  
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What can occur around a coarctation that can lead to or predispose someone to athlerosclerosis   Turbulent blood flow  
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In what condition would you see right ventricular hypoplasticity with an ASD and PDA   Pulmonic valve atresia  
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True or False: Neonates are capable of surviving a complete aortic valve atreia   FALSE  
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Which type of shunting takes place in a truncus arteriosus   R-->L  
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What must be present for a trunus arteriosus to occur   VSD  
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What must be presnet for survival in a transposition of Great Vessels   VSD or ASD with PSA (R-->L shunting)  
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Ishemic Heart disease makes up what % of cardiac deaths   80%  
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Angina, syncope and CHF are all clinical signs of what   Degenerative Calcific Aortic Valve disease  
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At what age do people with degenerative calcific aortic valve disease have symptoms   70-80  
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What valve is prone to NOT get infective endocarditis when it becomes clacified   Mitral  
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Which valve, when calcifed, will present with regurgitation with secondary arthymias   Mitral  
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Prolase of the mitral valve may be secondary to abnormalities in which tissue type   Marfans  
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In what age range does mitral valve prolapse occur   20-40  
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A MIDSYSTOLIC CLICK, with dyspnea, fatigue, phsychiatic problems and chest pain may be caused by what   mitral valve prolapse  
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Elogated or ruptured chordae tendinea would be a finding in which disorder   mitral valve prolapse  
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How is endocarditis diagnosed   blood culture  
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Where do emboli from endocarditis move to   spleen, kidney, brain and heart  
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Vegetations present on one or more vlaves would clue you into   endocarditis  
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erosions or perforations are indicative of what type of endocarditis   acute  
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What organism is usually the cause of endocarditis   Staph  
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Non-bacterial thrombi are seen in patients suffering from what?   Cancer, any condtion leaving them bed-ridden with a hypercoaguable state  
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Do non-bacterial thrmobi produce inflammation or valve damage   Nope  
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mitral and tricuspid fibrinoid necrosis, mucoid degeneration, and small/fibrinous sterile vegetations on leaflets are seen in which disease   Endocarditis via SLE  
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Vegetations from SLE endocardidtis have a tendency to embolize, true or false   false  
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What are the two types of artificial valves   Mechanical and bioprothestic (animal)  
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What percentage of patients experience endocarditis due to vlave replacement   5%  
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valve occulsion due to over growth and hemolysis are complications due to what   valve replacement  
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You suspect endocarditis, but upon examination you find fibrinoid necrosis and mucoid degeneration... what did this patient have   SLE  
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What is the recommmended HDL for males/females   > 35/45  
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Who's more likely to develop athlerosclerosis, men or women   MEN  
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The pooling/damaging effect of blood on the low pressure of a valve is refered to as...   Venturi Effect  
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Onionskin appearance   arteriolosclerosis  
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Ischemia without infarct is definitive of which disease   angina pectoris (stable, unstable, prinzmetal)  
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What are 90% of transmural MI's caused by   90% occulsion in the coronary arteries  
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