Cancer
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| List the four characteristics of a benign neoplasia | No metastisase, close resemblance to tissue of origin, necrosis is rare, no invasion
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| List the four characteristics of a malignant neoplasia | Metastases, invasive, necrosis is common, variable differentiation (poor resemblance to tissue of origin)
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| Neoplasia can be characterised into two: | 1. Proliferation in defiance of normal constraints 2. Invade and colonise territories reserved for other cells
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| Three things overactivity mutation can lead to | Mutation in coding sequence, gene amplification and chromosome rearrangement
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| How does genetic instability affect cells | 1. interfere with accurate replication of genome. 2. decreases efficiency of DNA repair 3. Increases occurrence of xsome breaks and rearrangements :. unstable/abnormal karyotype
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| 1. Detachment | Migration of individual cells enabled
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| 2. Invasion | Erosion of tissue boundaries
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| 3. Intravasation | Access to vascular routes of dissemination
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| 4. Evasion of host defences | Survival against host defences
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| 5. Arrest | Arrest of movement by adhesion to endothelium
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| 6. Extravasation | Colonisation of site of metastasis
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