Kidney 2 - autoregulation - Guyton
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| What is autoregulation in kidney? | Its a mechanism for maintaining constang bf and GFR
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| What is glomerulotubular balance? | tubules can adabt by changing reabsorbtion.
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| Describe the macula densas roll in autoregulation. | Slow flow rate -> incr. reab-> decr. NaCl concentration at macula d->decreased afferent arteriol resistens->incr. GFR<- constrict efferent arteriol<- angiotensin II<- renin<-macula densa
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| Between which limits does autoregulation work? | 75-160 mm Hg
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| Increased protien intake leads to? | incr. protein intake-> incr amino acid reabsorbtion ->incr. Na reab->detection in macula d->decr. resistans->incr GFR<-renin<-macula d
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| Increased glucose leads to? | Same as aminoacid intake.
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| Poisning lead to? | Poisonin->decr. tubule reab->incr. Na detection by macula densa->decr. GFR<-decr. renin
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| Autoregulation in vessels? | Myogenic effect->effect on bf and GFR
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| Sympatic effect on kidney? | sympatic ac-> constriction of renal arteriol-> decr. GFR
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| Severe hemorrage or brain ischemia leads to? | Sympatic activation-> decr. GFR
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| Endothelial damage leads to? | increased endothelin release->decr. GFR
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| Adrenal medulla releases x and has effect y? | x=NA, A. y=constriction of renal arteriols->decr. GFR
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| Decr. bf->Angiotensin II effect on ren? | constricts preferentially efferent arteriols-> decr. bf through peritubular capillaries->increased reabsorbtion ((angiotensin effect on efferent arteriol->incr. GFR
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| NO effect on GFR? | incr. because of dilatation-> decr. resistance
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| Effect of prostaglandin & bradykinin? | Incr. GFR
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| Aspirin effect on inflamation? | Inhibits prostaglandin->decr. GFR
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