Microcirculation - Guyton
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| How does the transport over capillary membrane occure? | Through intercellular cleft (glucose, Na,Cl), diffusion (through the cell membrane O2,Co2) and ((vesicle transport)).
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| What is the difference between capillaries in brain, liver, kidney and gi canal? | Brain has more tight junctions->only small molecules enters(O2,Co2, H2O), Liver cleft is wide open->plasma protiens can enter, kidney (glomerular)->fenestrae allow tremendous amount of small and ionic substances to pass through (but not plamsa protiens.
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| What is vasomotion? | Turning the sphincter on and off in arterioles and metarterioles produces a acountinuously flow.
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| How is vasomotion regulated? | Low [O2]->longer duration and higher frequency on vasomotion.
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| What is the meaning of average function of capillary system? | That we have 1)average rate of blood flow and capillary pressure 2)Average rate of transport through the capillaries.
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| What is diffusion? | Diffusion is a result from thermal motion of fluid and dissolved substances in the fluid.
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| What is the interstitum? | The space between the cells. And the fluid is called interstitial fluid.
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| What do we have between the cells in the intersitium? | We have 1) collagen fibers->tensional strenght 2)proteoglycans->fluid cant flow thorough.
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| What is the gel in the interstitium? | Its the filtered fluid from capillaries. It has almost the same constituents as plasma but has less protiens.
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| Why does 99% of the fluid diffuse in the interstitium? | Because of proteoglycans. In edema the fluid flow instead of diffusing because of the higher concentration of water.
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| The filtration through the capillaries is determined by? | 1)hydrostatic pressure 2)colloid pressure 3)capillary filtration coefficiens.
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| Describe the starling forces. | 1) Pc, capillary pressure 2)Pif - interstitial pressure 3)colloid osmotic pressure 4)interstitial fluid colloid osmotic pressure.
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| What is the net filtration pressure? | Ntp=outward - inward= net outward pressure
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