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amphetamine for biology of drugs

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Question
Answer
T or F: amphetamine is a stimulant   True  
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T or F: both cocaine and amphetamie stimulate the sympathetic nervous system   True  
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Sympathetic Nervous System is associated with _____-or-______ responses   Fight, Flight  
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T or F: ampheatime increases the same neurotrasmitters cocaine does   True  
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Amphetamines increase the brain levels of which 3 neurotrasmitters?   Dopamine, NE, Serotonin  
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Significance of increased levels of dopamine?   Euphoria  
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Significance of increased levels of norepinephrine?   sympathetic nervous system effects: increased heart rate, increased respiration rate, increased blood pressure, pupil dilation, etc.  
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Significance of increased levels of serotonin?   Alters mood  
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How do amphetamines increase neurotrasmitters levels differently than cocaine?   In addition to blocking reuptake like cocaine, the primary mechanism of amphetamines is to increase the release of those NTs.  
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T or F: amphetamine is metabolized in the liver, just like cocaine   FALSE  
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Where is amphetamine metabolized?   the bloodstream (but only partially metabolized)  
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T or F: continued amphetamine use can damage dopamine-containing neurons such as the substantia nigra   True  
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Substantia Nigra   part of the basal ganglia, it is a brain structure involved in dopamine, addiction, and movement  
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Parkinson’s disease   movement disorder caused by dopamine depletion in the substantia nigra  
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Symptoms of Parkinson’s disease   muscle rigidity, difficulty starting/stopping movements, slow/shuffling gait, “masked unexpressive face,” resting tremors, “pill rolling”  
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Explain connection between amphetamine abuse and Parkinson’s disease   amphetamine abuse can "exhaust" the substantia nigra, rendering it unable to make dopamine, causing symptoms of Parkinson’s  
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Low doses of amphetamine   increased social activity and energy  
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Psychological effects of amphetamine   aggression, appetite suppression  
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How does chemical structure of methamphetamine compare to amphetamine?   methamphetamine is amphetamine with a methyl group (CH3) attached  
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What is the effect of adding the methyl group to amphetamine?   Allows more of the drug to cross the blood-brain barrier  
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What are the 2 forms of methamphetamine?   d- and l-  
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Speed   mixture of d- and l- forms  
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Crank   d- form only  
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Which OTC drugs are used to make methamphetamine?   ephedrine or pseudoephedrine  
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Psychological effects of methamphetamine?   similar to amphetamine  
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Half-life of methamphetamine   9 to 15 hours  
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From which plant are ephedrine and pseudoephedrine extracted?   Ephedra aka Ma Huang  
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Created by: jondoh
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