Cocaine for Biology of Drugs
Help!
|
|
||||
|---|---|---|---|---|---|
| Effect of cocaine on the CNS? | Stimulant
🗑
|
||||
| Name some effects that result from cocaine stimulating the sympathetic nervous system | increased heart rate, sweating, dilated pupils, etc.
🗑
|
||||
| How did the natives in S. America use the leaves of the coca plant? | They chewed it
🗑
|
||||
| Faster rate of absorption: chewing coca leaves or smoking crack? | smoking crack
🗑
|
||||
| Shorter duration of effects: chewing coca leaves or smoking crack? | smoking crack
🗑
|
||||
| More extreme effects: chewing coca leaves or smoking crack? | smocking crack
🗑
|
||||
| T or F: addiction is more likely the faster the onset, the higher the intensity the effect, and the shorter the duration of effect | True
🗑
|
||||
| T or F: cocaine was once a key ingredient in popular drinks such as Coca-Cola and Vin Mariani | True
🗑
|
||||
| Does cocaine cross the blood-brain barrier? | Yes
🗑
|
||||
| Medical use for cocaine | local anesthetic with vasoconstriction
🗑
|
||||
| Describe cocaine’s mechanism of action as a local anesthetic | Blocks sodium ion channels, preventing the influx of sodium ions needed to depolarize the cell. Action potential cannot be generated. No message can be transmitted.
🗑
|
||||
| When were the 2 sharp spikes in usage during the past 100 years? | 1920s and 1980s
🗑
|
||||
| What percentage of users become addicted? | 15-20%
🗑
|
||||
| What are the relapse rates for recovering addicts? | 50-90%
🗑
|
||||
| What causes the feelings of euphoria? | Increased levels of dopmine
🗑
|
||||
| How does cocaine increase levels of dopamine? | it blocks re-uptake into the pre-synaptic vesicle by blocking the dopamine transporter
🗑
|
||||
| Cocaine blocks the re-uptake of which 3 neurotransmitters? | dopamine, NE, and serotonin
🗑
|
||||
| How many stages of cocaine overdose are there? | 3
🗑
|
||||
| OD Stage 1 | muscle twitching, vomiting, headaches, cold sweats
🗑
|
||||
| OD Stage 2 | seizures, rapid gasping breathing, drop in blood pressure
🗑
|
||||
| OD Stage 3 | paralysis, respiratory failure, cardiac arrest, fixed dilated pupils
🗑
|
||||
| Cocaethylene is the metabolite formed when cocaine is taken with which other drug? | Alcohol
🗑
|
||||
| How does cocaethylene compare to cocaine with regards to chemical structure and effects on the brain? | Effects on brain are the same; the chemical structure differs by one carbon atom
🗑
|
||||
| The effects of cocaine are __________ when taken with _______ because the resulting metabolite, cocaethylene, has similar effects on the brain | prolonged; alcohol
🗑
|
||||
| When did crack use become widespread? | @ 1985
🗑
|
||||
| Describe cocaine’s naturally occurring form and smokability | Cocaine HCl is an acid that is not smokeable
🗑
|
||||
| Crack = Cocaine HCl + _______ ___________ (baking soda) | sodium bicarbonate
🗑
|
||||
| Insufflation | the technical term for snorting
🗑
|
||||
| Psychological effects following a cocaine binge | depression, lack of motivation, paranoia
🗑
|
||||
| Some effects of cocaine use during pregnancy | increased risk for: low birth weight, premature delivery, miscarriage
🗑
|
||||
| T or F: some kids don’t seem to suffer any long term effects despite their mother’s cocaine use during pregnancy | True
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
jondoh
Popular Pharmacology sets