Drug Products Final
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Drugs must be in what form to pass membranes and get access to bodily fluids? | free form
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| Drugs will be more concentrated where they are _______. | ionized
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| Acidic Drugs are more concentrated in _______. | plasma
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| Basic drugs are more concentrated in ________. | milk
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| what percentage of the mother's drug dose ends up in mother's breast milk? | <5%
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| CYP3A4 and CYP2C9 do not reach full glucuronide conjugation capabilities until what age? | 6 months to a year
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| The rate of increase in drug concentration with time in the dissolution medium. | Drug Dissolution Rate
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| D = ____________. (Noyes Whitney Equation) | diffusion coefficient
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| S= _____________. | surface area
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| Cs= maximum ______________ of the drug in the saturated layer | solubility
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| C= ________________ of the drug in bulk solution | concentration
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| Cs-C= __________ ______________ between the diffusion layer and the bulk solution | concentration gradient
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| H=___________. | thickness
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| The driving force for dissolution is the _________ __________ between the diffusion layer and the bulk solution. | concentration gradient
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| In the "Cs-C" part of the NW equation, we can ignore the "____" term due to the fact that our body is an _______ _______. | infinite sink
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| The dissolution of solid into the medium. | Kdis
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| The absorption of the drug from the solution across the membrane | Kabs
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| Either the Kdis or the Kabs can be ________ _________. | rate limiting
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| drugs with _____________ water solubility tend to show membrane rate limited absorption | increased.
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| Concerning drugs with increased water solubility, the rate of dissolution is _______ than the rate of absorption | greater
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| drugs that are increasingly water soluble tend to cause ________ __________ due to large amounts of drug in solution at the membrane. | GI irritation
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| drugs with ___________ water solubility, tend to show dissolution rate limited absorption. (Kdis > Kabs) | decreased
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| Concerning drugs with decreased water solubility, the rate of dissolution is __________ than the rate of absorption. | less
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| For drugs that are __________, dissolution may be helpful in providing bioavailability. | DRLA
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| USP has several official methods for testing _________ dissolution | in vitro
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| __________ __________ method: sometimes criticized due to the fact the tablet is bouncing around inside the cage. | rotating basket
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| ____________ method ( one of the most popular methods for testing in vitro dissolution) | paddle
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| The faster the drug is dissolves, the higher the _________. | AUC
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| AUC and dissolution correlate for ___________ drugs. | DRLA
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| the better the dissolution, the ________ the extent of absorption. | higher
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| dissolution and ____________ may NOT be correlated. | disintegration
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| disintegration only shows how well the drug ________ ______, not if it goes into solution | breaks up
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| dissolution rates of ___________ formulations of a drug differ from that of the parent compound. | salt
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| salt form of a ______ ________ may also improve its pharmacological action. | weak acid
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| different salt forms change the dissolution of the drug at different ______. | rates
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| salt forms are sometimes undesirable when: the salt form has a lower _______________ than the free acid form. | bioavailability.
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| salt forms are sometimes undesirable when: _______ onset is NOT desired. | rapid
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| salt forms are sometimes undesirable when: the drug is _________ at low pH environments | unstable
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| _______________ is an example of an acid labile drug. | erythromycin
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