WVSOM -- Immuno/Micro -- Antibiotic List
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each of the black spaces below before clicking
on it to display the answer.
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| D-cycloserine | Cell wall synthesis; blocks addition of dipeptide to UDP-NAM - second step so no PEP attaches
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| Bacitracin | cell wall synthesis; blocks dephosphoralizatoin of bactoprenol phosphate- middle step transports ppg monomers across cell membrane
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| PCN | cell wall synthesis; beta-lactamases; last step of binding to transpeptidase to reform the peptide cross links
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| Cephalosporin | cell wall synthesis; beta-lactamases; last step of binding to transpeptidase to reform the peptide cross links
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| cephamycin | cell wall synthesis
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| fosfomycin | inhibits cell wall synthesis; inhibits phosphoenopyruvate transferase adn prevents formation of NAM -- first step does not occur
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| metronidazole | disrupts DNA helical structure under anaerobic conditions
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| Quinolones, flouroquinolones | inhibits DNA gyrase or topoisomerase
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| rifampin | binds to RNA polymerase
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| polymyxins | interact with phospholipids
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| macrolides, erythromycin, choramphenicol | 50S inhibitors; translation-protein synthesis
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| tetracyclines, aminoglycosides, streptomycin | 30S inhibitors; translation-protein synthesis
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| Linezolid | initiating complex blocked;
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| sulfonamides | folate antagonist; blocks synthesis of dihydropteroic acid
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| trimethoprim | folate antagonist; blocks synthesiss of tetrahydrofolate
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