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Test 1 drugs- AE, PD, CNS stimulants lilk8tob

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Drug
Info
phenobarbital- general class   barbiturate  
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phenobarbital- used for   prevention of grand mal seizures & fever-induced convulsions, hyperbilirubinemia in neonates, Gilbert syndrome  
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phenobarbital- other   long-acting, rarely used as a sedative-hypnotic agent  
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tamazepam (Restoril)- general class   benzodiazepines  
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tamazepam (Restoril)- used for   for short-term treatment of insomnia  
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tamazepam (Restoril)- other   not for narrow-angle glaucoma, preg X  
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zaleplon (Sonata)- general class   benzodiazepines  
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zaleplon (Sonata) used for   short term (up to 5 weeks) treatment of insomnia  
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zaleplon (Sonata)- other   short acting nonbenzodiazepine hypnotic agent. However, its hypnotic effects do arise from chem. activity @ benzo-GABA receptor complex; very short half-life  
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zolpidem (Ambien)- general class   benzodiazepines  
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zolpidem (Ambien) - used for   short term (7-10 days) treatment of insomnia  
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zolpidem (Ambien)- other   short acting, no active metabolites so have less grogginess next morning  
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baclofen (Lioresal)- general class   muscle relaxant  
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baclofen (Lioresal)- used for   spasticity  
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baclofen (Lioresal)- other   central-acting  
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cyclobenzaprine (Flexaril) - general class   muscle relaxant  
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cyclobenzaprine (Flexaril)- used for   spasticity  
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cyclobenzaprine (Flexaril)- other   central-acting; structurally and pharmacologically related to tricyclic antidepressants  
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choral hydrate (Noctec)- general class   misc. CNS depressant  
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choral hydrate (Noctec)- used for   sedative-hypnotic  
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choral hydrate (Noctec)- other   does not suppress REM; low hangover effect from short duration of action; high doses cause dependence; take w/ alcohol=lose consciousness  
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tizanidine (Zanaflex)- general class   misc. CNS depressant  
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tizanidine (Zanaflex)- used for   decreases increased muscle tone associated with spasticity  
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tizanidine (Zanaflex)- other   short-acting, centrally active alpha-adrenergic receptor agonist  
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List the 8 CNS depressant drugs:   phenobarbital, Restoril, Sonata, Ambien, baclofen, Flexaril, choral hydrate, Zanaflex  
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carbamazepine (Tegretol)- general class   AE  
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carbamazepine (Tegretol)- used for   treatment of epilepsy in adults & children, trigeminal neuralgia, tonic-clonic seizures  
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carbamazepine (Tegretol)- other   2nd most prescribed AED, chemically related to tricyclics; undergoes autoinduction  
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gabapentin (Neurontin)- general class   misc. AE  
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gabapentin (Neurontin)- used for   an add-on agent for the treatment of partial seizures & partial seizures w/ secondary generalization in adults, also treats neuropathic pain  
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gabapentin (Neurontin)- other   probably works by increasing the synthesis & accumulation between neurons in GABA  
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phenobarbital (Solfoton)- general class   barbiturate- AE  
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phenobarbital (Solfoton)- used for   controlling tonic-clonic and partial seizures; status epilepticus, convulsions  
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phenobarbital (Solfoton)- other   SE: sedation, an "inducer" of hepatic enzymes; has longest half life (once a day dosing), cheapest AE  
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phenytoin (Dilantin)- general class   AED  
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phenytoin (Dilantin)- used for   first-line AED; tonic-clonic; psychomotor seizures  
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phenytoin (Dilanin)- other   lethargy, abnormal movements, confusion, is highly protein bound & induces hepatic microsomal enzymes  
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valproic acid (Depakote)- general class   AE  
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valproic acid (Depakote)- used for   generalized seizures (absence, myoclonic, and tonic-clonic), partial seizures  
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valproic acid (Depakote)- other   toxic to liver, weight gain, sleepy, gum hypertrophy  
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Serum level: carbamaxepine (Tegretol)   6-12 mcg/ml  
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serum level- valproic acid (Depakote)   50-100 mcg/ml  
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serum level- phentoin (Dilantin)   10-20 mcg/ml  
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levodopa-carbidopa (Sinemet)- general class   antiparkinsonian - dopaminergic  
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levodopa-carbidopa (Sinemet)- used for   replaces dopamine in parkinson's patients  
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levodopa-carbidopa (Sinemet)- other   does not cross the BBB, but does prevent metabolism of levodopa to dopamine in the periphery, which limits peripheral dopamine-induced side effects; lower daily dose needed; limits on-off; do not take w/ MAOI's  
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selegiline (Eldepryl) -general class   MAOI - antiparkinsonian  
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selegiline (Eldepryl)- uses   parkinson's disease- decreases the amount of levodopa needed; exerts a neuroprotective effect when started early in therapy  
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selegiline (Eldepryl) - other   an MAO-B inhibitor used as an adjuncitve agent along w/ levodopa to decrease the amount of levodopa needed  
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benztropine mesylate (Cogentin)- general class   anticholinergic Antiparkinsonian  
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benztropine mesylate (Cogentin)- uses   Parkinson's disease; drug-induced extrapyramidal symptoms  
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methylphenidate hydrochloride (Ritalin)- general class   CNS stimulant, amphetamine  
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methylphenidate hydrochloride (Ritalin)- uses   treatment of ADHD and narcolepsy  
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list antiparkinsonian drugs (3)   levodopa-carbidopa, selegiline, Cogentin  
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list CNS stimulant   Ritalin  
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list AE drugs   Tegretol, Neurontin, Solfoton, Dilantin, Depakote  
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