Immunity lecture
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| Symptoms of SLE? | Protean: kidney, brain, heart, skin, joints
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| Triggers of SLE? | EBV, retrovirus
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| What are the autoimmune complexes of SLE? | anti-Ro,-La,-Sm,-RNP,-histone,-dsDNA,
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| Pathology of SLE? | Immune comlex mediated inflammation and tissue damage
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| What are the complications of SLE? | Premature atherosclerosis, infection
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| What are the symptoms of RA? | symmetrical pain, swelling, deformities of joints, morning stiffness, nodules
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| What are the triggers of RA? | EBV, smoking
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| What are the complications of RA? | Premature atherosclerosis, vasculititis
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| What is the trigger of systemic autoimmune disease? | Antigen (DNA, Ro, La, SM, RNP, Phospholipid) + Adjuvant = Immune response (innate) -> Adaptive immune response
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| What are the determinants of SLE? | Genes, Environment, Chance
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| How do they hypothesize that SLE is triggered? | Virus -> alpha IFN -> Production of Ro + Innate immune response (increase MHC production on cells) -> Anti-Ro Autoantibodies (Immune complex)
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| What do the endogenous and exogenous ligands do in SLE? | They activate TLR and increase IFN alpha production.
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| What impact of IFN alpha on dendritic cell maturation and class switiching have on disease SLE? | Autoimmunity
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| What impact does IFN gamma and chemokines as well as the destruction of endothelial progenitors have on the disease (SLE)? | inflammation and tissue damage
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| What are some general approaches to therapy of SLE? | Block CD28, CD40 on T cells; Cytokines; TLR, B cell targeting, complement system
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| Which 2 cytokines are heavy in RA? | TNF alpha and IL1
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| What are some things that you didn't know about TNF in RA? | Induces proinflam production, Promotes synoviocyte activation, maintiains inflammatory state in synovial membrane, induces osteoclast differentiation
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| What is the major costimulation in the adaptive immune system in RA? | CD40/CD40L; B7/CD28;
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Created by:
villagejoker
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