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Duke PA Gyn Infections

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
What is the lifetime risk of contracting an STD   1 in 4  
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What age group is the highest at risk population   15-24  
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What geographic regions are at highest risk for STD’s   southeast and urban  
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History of sexual intercourse with trauma increases the risk for what STD   Hep B , and Hep C  
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Why would you check the palms of a patient when concerned about STD’s   you are looking for secondary syphilis  
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3 causes of genital ulcers in US   Herpes simplex virus, primary syphilis, chancroid  
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Herpes ulcers are __   Painful, small, shallow, may have a clear exudate  
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Secondary herpes ulcers are __   Smaller, and less dramatic looking than the primary lesions  
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Primary syphilis is a __   Solitary, painless, indurated, large/deep ulcer  
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Agent responsible for chancroid   H. ducreyi  
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Clinical presentation of lymphogranuloma venereum (LGV)   Rectal ulceration or stricture, inguinal LAD.  
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Etiology of LGV   Chlamydia trachomatis  
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Clinical presentation of granuloma inguinale   Chronic or recurrent ulcerative vulvitis. Donovan bodies on stained direct smear or biopsy of ulcer.  
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What is the etiologic agent of granuloma inguinale   Calymmatobacterium granulomatous  
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What is the etiologic agent of condyloma acuminata   HPV  
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What is the clinical appearance of condyloma acuminata   Papillomatous, white, cauliflower like  
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Vaccine available for HPV   Gardasil  
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Who should Gardasil be offered to   Females 9-26 years old (full benefit if given prior to onset of sexual activity) even if history of hpv  
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Secondary syphilis usually only lasts for __   A few weeks  
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Clinical appearance of secondary syphilis   Bilaterally symmetrical papulosquamous rash, condyloma, alopecia, denuded tongue, lymphadenopathy (firm, rubbery, non-tender)  
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Secondary syphilis is contagious by __   Skin on skin contact (any portion of the body)  
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Latent syphilis   period after secondary stage, no clinical manifestation  
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Tertiary syphilis is __ infectious   Rarely  
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Primary diagnosis of syphilis   Darkfield microscopy of chancre  
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Diagnosis of neurosyphilis   CSF examination recommended in symptomatic, late-latent, HIV co-infection (lumbar puncture)  
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What is herpetic whitlow   Herpes on the fingers (especially around the nail bed)  
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Characteristic of primary HSV outbreak   2-7 day course, systemic symptoms possible, local symptoms (painful), first outbreak is the worst  
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Precipitants of HSV recurrent outbreaks   Sun, wind, trauma, fever, menses, stress  
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__ may reduce transmission of HSV   Antivirals  
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What type of bacterium is chlamydia trachomatis   Intracellular obligate bacteria  
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What is the most commonly reported STI in the US, >1 million infections in 2006   Chlamydia  
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Who should be tested for chlamydia   Women<26 yo annually, new sex partner in past 60 days, >2 sex partners in past year, exam findings of cervical mucopus/friability/ectopy  
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If you are treating a patient for gonorrhea what else should you treat for   Chlamydia  
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If you are treating a patient for chlamydia do you need to also treat for gonorrhea   Not necessarily  
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Clinical course of chlamydia   Asymptomatic or minor symptoms in majority, vaginal discharge, dysuria, mucopurulent cervicitis, acute urethral syndrome, pelvic pain, lower abdominal pain  
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Perinatal transmission of chlamydia can cause __   Ophthalmia neonatorum, pneumonia  
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Female chlamydia complications   PID, infertility, ectopic pregnancy, perihepatitis, perinatal transmission  
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What type of bacterium is Neisseria gonorrhea   Gram negative intracellular diplococcus  
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What is the 2nd most commonly reported infectious disease in the US   Gonorrhea  
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Symptoms of gonorrhea   Vaginal discharge, abdominal pain, 50% asymptomatic  
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Female complications of gonorrhea   PID, infertility, ectopic pregnancy, tubo-ovarian abscess, perihepatitis (Fitz-Hugh-Curtis syndrome), septic arthritis, vertical transmission, ophthalmia neonatorum  
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Offer __ testing for all patients evaluated for STIs   HIV  
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Acute HIV symptoms   Fever, mono-like illness, diarrhea  
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Which hepatitides are commonly sexually transmitted   A, B, and C (especially B)  
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Vaccinations are available for which hepatitides   A and B (no hep C vaccine available yet)  
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Males voiding within __ before urethral culture washes secretions away   1-2 hours  
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Best source of HSV for testing   Unroofing the vesicle  
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Gold standard for HSV testing   Culture  
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__% of US population have positive herpes antibodies on serological testing   50  
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Etiology of syphilis   Treponema pallidum spirochete  
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How many stages of syphilis are there   4  
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Characteristic of acute syphilis. Chancre develops on skin near infection site about __ after inoculation   3-6 weeks  
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Characteristic of secondary syphilis   Maculopapular rash often on palms and soles, generalized lymphadenopathy, typically lasts about 3 months  
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How long does the acute syphilitic chancre last   5-6 weeks  
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How long may syphilis remain inactive   Up to 5 years  
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About how many patients with latent syphilis progress to tertiary phase   2/3  
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What is tertiary syphilis   End organ manifestation, including CNS, cardiovascular and ocular  
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VDRL becomes positive __ after inoculation with Syhpilis   About 2 weeks  
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What will gram stain show for positive Gonorrhea infection   Gram negative intracellular diplococci  
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If a patient is infected with Gonorrhea they are probably also infected with __   Chlamydia  
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What is the etiology of Chancroid   Haemophilus ducreyi  
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Chancroid is most often a co-infection with what   Herpes and or syphilis  
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Gram stain with a “school of fish” appearance is probably what   Chancroid (Haemophilus ducreyi)  
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What is the most frequently occurring STD in developed countries   Chlamydia  
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Chlamydia is most prevalent in what population   <20 yr olds, nulliparous, users of non-barrier contraceptive methods  
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What are the 4 methods for diagnosis of HIV   Detect antibodies to the virus, detect viral p24 antigen, detect viral nucleic acid, culture HIV virus  
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What is the most widely used method to diagnose HIV   Detection of antibody to HIV  
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What is the most common cause of false positive tests for HIV in low risk patients   Recent immunization  
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What is the initial screening for HIV   EIA enzyme immunoassay (EILISA)  
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What is the confirmatory test for HIV (done after the screening test)   Western blot or IFA (Immunofluorescence Assay)  
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Multiple, vesicular, pruritic, painful, recurrent rash   Herpes simplex  
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Single, heaped up or rolled edge, textbook case never painful   Syphilitic chancre  
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Most appropriate way to test for herpes   Culture (not serological)  
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Trichomonas is tested for by use of what   Wet prep  
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Treatment for contact dermatitis   1% hydrocortisone cream and removal of offending agent  
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What causes the fishy odor in bacterial vaginosis   Anaerobes  
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What do you look for on microscopic examination to show the presence of bacterial vaginosis   Clue cells (epithelial cells with irregular borders in clusters, very shiny)  
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Bacterial vaginosis requires 3 of 4 criteria. What are the 4 criteria   Typical discharge, alkaline pH(5.0-5.5), positive “whiff” test, clue cells on wet prep  
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Bacterial vaginosis is not considered an __   STD  
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Treatment for bacterial vaginosis   Metronidazole or clindamycin, topical or orally  
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Should you treat male partners of women with bacterial vaginosis   No  
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Signs and Symptoms of trichomonas vaginitis   Severe pruritus, malodorous (musky) discharge, dysuria, dyspareunia, may be asymptomatic, greenish-yellow/frothy discharge, petechiae or “strawberry markings on cervix  
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Treatment for trichomonas vaginitis   2gm metronidazole stat, treat partners, look for other STDs  
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Treatment for yeast vaginitis   Over the counter imidazoles, oral fluconazole 150mg stat  
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Atrophic vaginitis often masquerades as what   Infection  
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Signs and symptoms of atrophic vaginitis   Pruritis/burning, vaginal dryness, dyspareunia, possibly spotting, pale/thin vaginal mucosa, loss of vaginal rugation  
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Bilateral Bartholin’s abscess said to be associated with what   Gonorrhea  
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Treatments for Bartholin’s gland abscess if not pointing   Antibiotic treatment may be successful  
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Treatment for Bartholin’s gland abscess   I&D and placement of Word catheter (left in for 1-2 weeks), marsupialization, needs to remain open to avoid recurrence  
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What organism is associated with toxic shock syndrome   S. aureus/endotoxins  
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Woman with flu like symptoms, on her period think   Toxic shock syndrome  
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CDC case definition of __ ; fever >38.9 C, hypotension, diffuse erythroderma, desquamation, involvement of at least 3 organ systems   Toxic shock syndrome  
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Treatment for toxic shock syndrome   Supportive, look for foreign body in vagina and remove, clindamycin and oxacillin/nafcillin, MRSA: clindamycin and vancomycin/linezolid  
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Common condition in which microorganisms spreads from the lower genital tract infect and inflame upper genital tract structures including the endometrium, tubes, ovaries and peritoneum   Pelvic inflammatory disease  
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Symptoms of PID   Abdominal pain, dyspareunia, possibly fever/chills, possibly RUQ pain  
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Start empiric treatment for these 3 CDC minimum criteria for PID   Lower abdominal tenderness, adnexal tenderness, cervical motion tenderness  
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In addition to the 3 CDC minimum criteria what are the additional criteria for PID   Elevate oral temp (>101), abnormal cervical or vaginal discharge, elevated ESR, Elevated C-reactive protein, positive GC or chlamydia, increased WBC  
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Which PID patients need hospitalization   Nulliparous/adolescents/non compliant, pregnant, treatment failure, HIV/immunosuppression, unable to tolerate oral regimen, Tubal ovaria cyst, severe peritonitis/uncertain diagnosis  
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Violin string adhesions between liver and parietal peritoneum, RUQ pain may be prominent symptom especially in young women, PID complication   Fitz-Hugh-Curtis syndrome  
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What cancer is a sexually transmitted infection caused by HPV   Cervical cancer  
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Risk factors for cervical cancer   Smoker, hormones, multiple sexual partners, sex before 18, HIV, poor SES, age, multiple pregnancies, chlamydia infection, diet low in fruit and vegetables  
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Effective methods to prevent cervical cancer   Routine pap tests, avoid smoking, condom use, limit partners, HPV vaccine  
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Low risk HPV strains   HPV-6, and HPV-11 (cause genital warts)  
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High risk strain   HPV-16 and HPV-18  
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What is the HPV vaccine   Gardasil (HPV 6,11,16,18)  
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Bilateral papulosquamous rash on palms and soles   Secondary syphilis  
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