TB facts from lecture
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What are the most important symptoms of TB? | Cough w/ or w/out hemoptysis, fever, chills, night sweats, weight loss, poor appetitie
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| What are teh common sites of TB? | Lungs, pleura, CNS, lymphatics, GU system, bones and joints , disseminated (miliary TB)
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| Is Latent TB contagious? What is treatment? | No it isn't. Prophylaxis with isoniazid for 6-9months reduces risk of progression by 90%.
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| What are the disadv of TST? | False +s due to cross rxsn with BCG, 2 patient visits, inter reader variability
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| What are the advantages of QFt? | TB specific antigens, 1 patient visit, minimal inter reader variability
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| How many people develop TB if infected? | 10%
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| What are the conditions that increase the risk of TB progression? | HIV, recently acquired infection, DM, Silicosis, Corticosteriods + other immunosuppressive therapy, Cancer of head and neck, hematologic and reticuloendothelial diseases, end stage renal disease, History of malabspsorption syndromes
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| What is the contagiousness of TB? | It is airborne, it depends on environment, duration of exposure, virulence of organism and infectiouness of person with TB
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| What are the side effects of isoniazid? | Peripheral neuropathy, hepatitis, liver failure, sleepiness/lethargy
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| What are the side effects of Pyrazinamide? | Joint pains, hepatitis, Rash
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| What are the side effects of Ethambutol? | Optic neuritis, decreased red/green colour discrimination
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| What are the side effects of Rifampin? | GI upset, orange discoloration of body secretions
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| How does Rifampin influence metabolism of other drugs? | It upregulates p450 cytochrome,therefore it decreases drug levels
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| How do you get MDRTB? | Acquired - noncompliance/inappropriate therapy Primary - Infected with a drug resistant strain
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| What are the genotyping techiniques used in NYC? | RFLP and Spoligotyping
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Created by:
villagejoker
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