WVSOM Autonomics Pharmacology
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| Brimonidine | (Alphagan) a2 selective agonists – used topically on the eye
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| Apraclonidine | (lopidine) a2 selective agonists – used topically on the eye
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| Xylometazoline | a1 selective agonists(Chlorohist-LA, Inspire, Neo-Synephrine II Long Acting, Otrivin) Used nasally
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| Oxymetazoline | a1 selective agonists (Afrin, Neo-Synephrine 12 Hours, etc.) – also activate a2. Used for nasal
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| Midodrine | a1 selective agonists(ProAmatine) – oral
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| Brimonidine | (Alphagan) a2 selective agonists – used topically on the eye
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| Apraclonidine | (lopidine) a2 selective agonists – used topically on the eye
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| Isoproterenol | non-selective Beta agonist (must be given parentally)
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| Dobutamine | Beta1 selective agonist, also acts on some Beta2's and alpha receptors (must be given parentally)
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| Albuterol | (Proventil, Ventolin, etc.) b2 selective agonists – given as inhalation
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| Metaproterenol | (Alupent, Metaprel, etc.) b2 selective agonists – given as inhalation
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| Bitolterol | (Tornalate) b2 selective agonists – given as inhalation
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| Pirbuterol | (Maxair) b2 selective agonists– given as inhalation
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| Terbutaline | (Brethine, Bricanyl, etc.) b2 selective agonists. Can be given orally or parentally
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| Salmeterol | (Serevent) – b2 selective agonists. Given as inhalation
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| Formoterol | (Foradil Aerolizer, Foradil Certihaler) b2 selective agonists. given as inhalation
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| Arformoterol | (Brovana) b2 selective agonists. given as inhalation
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| Phenylephrine | Topical Nasal Decongestant - acts on a1'sSHORT DURATION
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| Xylometazoline | Topical nasal decongestant - acts on a1'sLong duration
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| Oxymetazoline | topical nasal decongestant -acts on a1'sLong duration
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| Prazosin | (Minipress) - a1 selective antagonist, reversible
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| Terazosin | (Hytrin)a1 selective antagonist , reversible
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| Doxazosin | (Cardura)a1 selective antagonist, reversible
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| Tamsulosin | (Flomax)a1 selective antagonist , reversible
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| Alfuzosin | (Uroxatral)a1 selective antagonist, reversible
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| Phentolamine | Non-selective alpha antagonist REVERSIBLE
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| Phenooxybenzamine | nonselective alpha antagonist IRREVERSIBLE
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| Prazosin (Minipress) | alpha-antagonist - used to treat hypertension
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| Terazosin | alpha antagonist - used to treat hypertension
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| Doxazosin | alpha antagonist- used to treat hypertension
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| Phentolamine | alpha antagonist - used to treat pheochromocytoma
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| Phenoxybenzamine | alpha Antagonist - used to treat pheochromocytoma
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| What are the three drugs used to treat pheochromocytoma | Prazosin, Phentolamine, and Phenoxybenzamine
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| Terazosin | - Trests BPH (a-blocker)
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| Doxazosin | - Treats BPH (a-blocker)
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| Tamsulosin | - Treats BPH (a-blocker)
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| Alfuzosin | - treats BPH (a-blocker)
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| Prazosin | a-blocker, used to treat Raynauds
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| Propranolol | (Inderal) - b Receptor Antagonists: Non-selective, competitive, reversible
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| Nadolol | (Corgard) - b Receptor Antagonists: Non-selective, competitive, reversible
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| Timolol | (Blocadren, Timoptic, Betimol) - b Receptor Antagonists: Non-selective, competitive, reversible
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| Pindolol | (Visken) - b Receptor Antagonists: Non-selective, competitive, reversible
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| Carteolol | (Cartrol, Ocupress) - b Receptor Antagonists: Non-selective, competitive, reversible
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| Levobunolol | (Betagan) - b Receptor Antagonists: Non-selective, competitive, reversible
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| Metoprolol | (Lopressor, Toprol XL) - b1 selective, competitive, reversible
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| Atenolol | (Tenormin) - b1 selective, competitive, reversible
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| Acebutolol | (Sectral) - b1 selective, competitive, reversible
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| Betaxolol | (Betoptic, Kerlone) - b1 selective, competitive, reversible
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| Levobetaxolol | (Betaxon)The S-isomer of racemic betaxolol. b1 selective, competitive, reversible
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| Bisoprolol | (Zebeta)- b1 selective, competitive, reversible
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| Esmolol | (Brevibloc) - b1 selective, competitive, reversible
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| What is BEAM used to identify | ALL B1 antagonist start with B E A or M
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| Acetylcholine | Direct Acting Muscarinic Agonists
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| Methacholine | Direct Acting Muscarinic Agonists
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| Bethanechol | (Urecholine) - Direct Acting Muscarinic Agonists. Works specfically on the badder and GI tract
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| Pilocarpine | (Pilocar, Etc., - topical/ Salagen - oral) - Direct Acting Muscarinic Agonists
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| Carbachol | (Isopto Carbachol, Carboptic, Miostat) - direct acting muscarinic agonsit
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| Cevimeline | (Evoxac) - direct acting muscarinic agonist
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| Muscarine | Direct acting muscarinic agonist
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| Why is ACh not used as a drug | Short half-life, way too non-specific, and not very good at reaching target
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| What is Bethanechol used for | works on the bladder and GI tract
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| Can Bethanechol be used for obstructive GI problems | NO, only used for non-obstrutive
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| Pilocarpine is used orally to treat what | Radiation caused dry mouth and Sjogrens syndrome
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| Pilocarpine is used topically to treat what | Open and narrow angle glocoma, and caue Miotic effects
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| What advatages does Cevimeline have over pilocarpine | Long lasting, less side effects and only needs to be taken 2-3 times per day
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| What is Carbachol | 2nd line drug in the treatment of glocoma
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| Donepezil | (Aricept, Aricept ODT)- Reversible AChE Inhibitors. WORKS ON CNS
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| Tacrine | (Cognex)- Reversible AChE Inhibitors. WORKS ON CNS
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| Rivastigmine | (Exelon) - Reversible AChE Inhibitors. WORKS ON CNS
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| Galantamine | (Razadyne)- Reversible AChE Inhibitors. WORKS ON CNS
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| (Mestinon, Mestinon Timespan)- Reversible AChE Inhibitors
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| Ambenonium | (Mytelase)- Reversible AChE Inhibitors
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| Demecarium | (Humorsol) - Reversible AChE Inhibitors
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| Donepezil | (Aricept, Aricept ODT)- Reversible AChE Inhibitors. WORKS ON CNS
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| Tacrine | (Cognex) - Reversible AChE Inhibitors. WORKS ON CNS
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| Rivastigmine | (Exelon) - Reversible AChE Inhibitors. WORKS ON CNS
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| Galantamine | (Razadyne) - Reversible AChE Inhibitors. WORKS ON CNS
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