Growth Factors & cytokins involved in reegeneration & wound healing - POD test 3
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| EGF stands for | Epidermal Growth Factor
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| Source of EGF | Platelets, macrophages, saliva, urine, milk, plasma
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| Functions of EGF | Mitogenic to epithelial cells and fibroblasts in vitro
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| This growth factor is widely distributed in tissue secretion and fluids | EGF (Epidermal Growth Factor)
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| TGF-alpha stands for | Transforming growth factor alpha
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| Source of TGF-alpha | Macrophages, T lymphocytes, keratinocytes, and many tissues
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| Functions of TGF-alpha | Stimulates replication of hepatocytes and certain epithelial cells
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| HGF stands for | Hepatocyte growth factor/scatter factor
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| Source of HGF | Mesenchymal cells
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| Functions of HGF | Enhance proliferation of epithelial and endothelial cells, and of hepatocytes; increases cell motility
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| VEGF stands for | Vascular endothelial cell growth factor
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| Source of VEGF | Mesenchymal cells
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| Functions of VEGF | Increases vascular permeability; mitogenic for endothelial cells
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| PDFG stands for | Platelet-derived growth factor
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| Source of PDGF | Stored in platelet alpha-granules and released upon platelet activation
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| PDGF is produced by | activated macrophages, endothelial cells, smooth muscle and tumor cells
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| PDFG causes | migration and proliferation of fibroblasts, smooth muscle cells and monocytes.
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| FGF stands for | Fibroblast Growth Factors
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| FGF causes | migration of macrophages, fibroblast and endothelial cells in damaged tissue, and migration of epithelium to form new epidermis
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| TGF-beta stands for | Transforming growth factor beta
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| TGF-beta is produced by | platelets, endothelial cells, lymphocytes and macrophages
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| Function of TGF-beta | Stimulate fibroblast chemotaxis; stimulates production of collagen and fibronectin; decreases collagen degradation
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| This peptide is a growth INHIBITORY factor in epithelial cells and fibroblasts and smooth muscle cells at high concentrations, and STIMULATORY factor in fibroblasts and smooth muscle cells at low concentrations. | TGF-beta
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| This growth factor is mitogenic to epithelial cells and fibroblasts in vitro. | EGF
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| This growth factor causes hepatic cell division in vivo. | EGF
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| This growth factor is stored in platelet a-granules and released upon platelet activation. | PDGF
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| This growth factor is produced by activated macrophages, endothelial cells, smooth muscle and tumor cells. | PDGF
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| This growth factor causes migration and proliferation of fibroblasts, smooth muscle cells and monocytes | PDGF
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| This growth factor is involved in angiogenesis and wound repair. | FGF
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| This growth factor causes migration of macrophages, fibroblasts and endothelial cells in damaged tissue. | FGF
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| This growth factor causes migration of epithelium to form new epidermis during wound repair. | FGF
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| These two growth factors are responsible for angiogenesis. | FGF and VEGF
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| This growth factor is produced by platelets, endothelial cells, lymphocytes and macrophages | TGF-beta
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| This growth factor stimulates fibroblast chemotaxis. | TGF-beta
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| This growth factor stimulates production of collagen and fibronectin. | TGF-beta
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| This growth factor decreases collagen degradation. | TGF-beta
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| These three factors favor fibrogenesis and are functions of TGF-beta. | Fibroblast chemotaxis, production of collagen and fibronectin, decrease of collagen degradation.
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| High concentrations of TGF-beta have what kind of effect in fibroblasts and smooth muscle cells? | Growth inhibition
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| Low concentrations of TGF-beta have what kind of effect in fibroblasts and smooth muscle cells? | Growth stimulation
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