Anti-neoplastics
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| Folic acid analog that inhibits dihydrofolate reductase | Methotrexate
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| Pyrimidine analog that inhibits thymidylate synthase | 5-fluorouracil
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| Inhibitor of de novo purine synthesis | 6-mercaptopurine
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| Inhibits DNA polymerase | cytarabine
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| Alkylating agents used to treat Non-Hodgkin lymphoma, breast and ovarian carcinoma. Notable side effect of hemorrhagic cystitis | Cyclophosphamide, ifosfamide
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| Alkylating agent capable of crossing blood brain barrier | Nitrosureas (carmustine, lomustine)
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| Similar to alkylating agent, notable toxicities include nephrotoxicity and acoustic nerve damage | Cisplatin, carboplatin
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| Alkylating agent used to treat CML | Busulfan
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| Free radical generator and also intercalates DNA to from strand breaks ("A" in ABVD treatment for Hodgkins) | Doxorubicin (Adriamycin), daunorubicin
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| Used to treat childhood tumors (Wilm's tumor, rhabdomyosarcoma, and Ewing's sarcoma) | Dactinomycin (Actinomycin D; Children ACT out)
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| Free radical generator which can cause life threatening pulmonary fibrosis | Bleomycin
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| Topoisomerase II inhibitor | Etoposide
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| Steroid that triggers apoptosis | Prednisone
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| Estrogen receptor antagonist | Tamoxifen
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| Monoclonal antibody against HER-2 | Trastuzumab
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| Philadelphia chromosome bcr-abl tyrosine kinase inhibitor | Imatinib (Gleevec)
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| Binds tubulin blocking polymerization of microtubules and mitotic spindle formation | Vincristine, vinblastine
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| Binds tubulin hyperstabalizing microtubules and blocking mitotic spindle formation | Paclitaxel
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| Toxicity includes Cushing-like symptoms | Prednisone
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| Used for "metastatic" breast cancer | Trastuzumab
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| Increased risk of endometrial carcinoma | Tamoxifen
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| Do not use with allopurinol | 6-mercaptopurine (activated by xanthine oxidase; allopurinol is a xanthine oxidase inhibitor used to treat gout)
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| CNS toxicity | Nitrosureas (carmustine, lomustine
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| Reversible myelosuppression with leucovorin rescue | Methotrexate
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| Neurotoxic (areflexia, peripheral neuritis) paralytic ileus | Vincristine (Vinblastine is notable for bone marrow suppression)
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| Antineoplastic used for therapeutic abortion | Methotrexate
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| Androgen receptor antagonist | Flutamide
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| Recombinantly produced cytokine used to treat hairy cell leukemia | Interferon alpha
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| GnRH agonist used for the treatment of metastatic prostate carcinoma | Leuprolide, Goserelin, Nafarelin
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| Monoclonal antibody used for treatment of low grade non-Hodgkin lymphoma | Rituximab
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| Aromatase inhibitor used to treat breast cancer | Anastrozole
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