Duke PA Behavioral Health Pharmacology
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| most clinically useful antidepressant drugs potentiate, either directly or indirectly the actions of _______ in the brain | norepinephrine and or serotonin
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| Selective Serotonin Reuptake Inhibitor | Citalopram
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| Selective Serotonin Reuptake Inhibitor | Escitalopram
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| Selective Serotonin Reuptake Inhibitor | Fluoxetine
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| Selective Serotonin Reuptake Inhibitor | Fluvoxamine
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| Selective Serotonin Reuptake Inhibitor | Paroxetine
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| Selective Serotonin Reuptake Inhibitor | Sertaline
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| Serotonin/Norepinephrine re-uptake Inhibitors | Duloxetine
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| Serotonin/Norepinephrine re-uptake Inhibitors | Venlafaxine
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| Atypical Antidepressants | Bupropion
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| Atypical Antidepressants | Mirtazapine
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| Atypical Antidepressants | Nefazodone
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| Tricyclic Antidepressants | Trazodone
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| Tricyclic Antidepressants | Amitriptyline
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| Tricyclic Antidepressants | Clomipramine
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| Tricyclic Antidepressants | Desipramine
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| Tricyclic Antidepressants | Doxepin
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| Tricyclic Antidepressants | Imipramine
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| Tricyclic Antidepressants | Maprotiline
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| Tricyclic Antidepressants | Nortriptyline
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| Tricyclic Antidepressants | Protriptyline
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| Tricyclic Antidepressants | Trimipramine
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| Monoamine Oxidase Inhibitors | Phenelzine
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| Monoamine Oxidase Inhibitors | Selegiline
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| Monoamine Oxidase Inhibitors | Tranylcypromine
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| Drugs used to treat mania and Bipolar disorder | Carbamazepine
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| Drugs used to treat mania and Bipolar disorder | Lithium salts
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| Drugs used to treat mania and Bipolar disorder | Valproic acid
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| Selective Serotonin Reuptake Inhibitor | Have little blocking activity at muscarinic, alpha-adrenergic, and histaminic H1 receptors
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| Selective Serotonin Reuptake Inhibitor | have largely replaced tricyclic antidepressants and monoamine oxidase inhibitors as DOC in treatment of depression
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| antidepressants take ____ weeks to show a significant improvement in mood | 2
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| Selective Serotonin Reuptake Inhibitor | about 1/50 adolescents become more suicidal as a result of treatment with this antidepressant
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| Selective Serotonin Reuptake Inhibitor | has a lower adverse effect profile compared to other antidepressants
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| The SSRI with the lowest risk of causing an SSRI discontinuation syndrome | Fluoxetine
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| sometimes effective in relieving neuropathic pain such as diabetic peripheral neuropathy | SNRI's and tricyclics
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| not recommended in patients with end stage renal disease | Duloxetine
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| should not be administered in patients with hepatic insufficiency | Duloxetine
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| is unique in that it assists in decreasing the craving and attenuating the withdrawal symptoms for nicotine | Bupropion
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| Is markedly sedating due to its antihistaminic activity, can also cause increased appatite and weight gain | Mirtazapine
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| has been associated with causing priapism | Trazodone
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| Uncommon side effects for SSRI's | orthostatic hypotension, sedation, dry mouth, and blurred vision
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| TCAs are effective in treating moderate to severe depression. Some patients with ____ also respond to TCAs | panic disorder
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| The TCA Imipramine has been used to control | bed wetting in children
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| The TCA Amitriptyline has been used to treat | migraines
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| Blockade of muscarinic receptors leads to | blurred vision, xerostomia, urinary retention, constipation, and aggravation of narrow angel glaucoma
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| Blockade of alpha-adrenergic receptors leads to | orthostatic hypotension, dizziness, and reflex tachycardia
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| common AE of TCA | weight gain
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| Occurs in a significant minority of patients on TCA's as compared to SSRI's | sexual disfunction
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| TCA's should be used with caution in known manic depressives because they may | cause manic behavior
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| Depressed patients should only be given limited quantities of TCA's because | of their narrow therapuetic window
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| MAOI's have a ____ effect | amphetamine like stimulant
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| MAOI's are idicated for | patients allergic/unresponsive to TCA's
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| TCA's are an important alternative to | SSRI's
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| This limits the widespread use of MAOI's | unpredictable side effects due to food and drug interactions
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| Considered a mood stabilizer, it is not a sedative, euphoriant, or depressant | Lithium salts
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