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WVSOM -- Respiratory System under Stress

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Question
Answer
How does ventilation change with increased arterial Pco2?   Increased ventilation  
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Which chemoreceptors are mainly stimulated?   central chemoreceptors  
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How does ventilation change in hypoxia?   increased ventilation  
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Which chemoreceptors are mainly stimulated?   peripheral chemoreceptors  
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What happens to Inspired PO2 with increase in altitude?   drops  
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What happens as barometric pressure drops?   PIO2 drops  
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What is the barometric pressure at the top of Mt. Everest?   43mmHg  
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Does PO2 drop with altitude?   no it is just less dense so only Inspired PO2 is decreased  
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What 4 things help us acclimate to high altitude?   hyperventilation, polycythemia, O2 dissociation curve and circulatory changes  
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How does Hyperventilation help with high altitudes?   There is an increase in Alveolar PO2 by decreasing the PAco2. You basically blow off more CO2  
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How does ventilation increase in two stages during alveolar hypoxia?   Arterial and CSF pH correction allows ventilation to increase further. Alkalosis then limits hyperventilation.  
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What are the effects of acute mountain sickness are attributable to hypoxemia and alkalosis?   headach, dizziness, palpations, fatuge, nausea, loss of appetite and insomnia  
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What is polyctyhemia?   increase in red blood cells  
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How does polycythemia help in high altitude?   helps normalize blood O2 content  
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How is polycythemia bad?   Increased viscosity  
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What happens to the O2 dissociation curve at high altitude?   Shifts left  
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What happens to the O2 disassociation curve at moderate altitude?   Curve shifts to the right so that it is more willing to release O2  
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What systemic changes happen at high altitude?   more capillary formation and mitochondrial enzyme expression to maintain the gradient  
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What happens to pulmonary circulation at high altitudes?   Hypoxic vasoconstriction which is not helpful. It happens all over the lung instead of localized  
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What happens with prolonged breathing of pure O2?   it is toxic. Person has convulsions, pulmonary edema and decreased vital capacity  
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Why can breathing pure oxygen be toxic?   It splints N2 and causes absorption atelectasis  
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What is absorption atelectasis?   Pure O2 will cause wash out all the N2 in your alveoli and blood and there will be a much longer partial pressure that will lead to airway collapse  
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How does Hyperbaric O2 useful in CO poisoning?   Increased barometric pressure with increased PIO2 will lead to an increased dissolved O2 in the blood  
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What does Nitrogen and sulfur oxides do to the lung?   causes inflammation  
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What does ozone do to the lung?   causes extra edema in the lung  
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What do hydrocarbons do to the lung?   carcinogenic  
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Why is CO bad?   it binds to hemoglobin so O2 can’t  
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Where do large particles deposit in the lung?   nasopharynx. They are removed by swallowing  
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Where does does sedimentation deposit in the respiratory system?   they are medium particles that deposit in small airways  
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Where do small particles deposit in the lungs?   alveoli  
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What is coal miners pneumoconiosis?   deposition of coal dust in respiratory bronchioles  
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What does cigarette smoke do to the lungs?   increased resistance  
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What does the ductus arteriosus do?   shunts blood away from the lungs.  
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Why is blood shunted away from the lungs in an embryo?   lungs do not need blood because no diffusion is going on.  
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What is the purpose of the foramen ovale?   directs oxygenated blood to the heart and blood  
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Why is placental gas exchange NOT efficient?   The blood flows haphazard around and the blood supply is in parallel so oxygenated blood mixes with de-oxygenated blood  
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What are the respiratory changes at birth: switching from placental to lung gas exchange?    
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