Epidemiology: Derm, Hem-Onc, Renal, Neuro
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| Psoriasis | 2.1% of US adults (4.5M); 1M psoriatic arthritis; 200K new cases/yr
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| Achrocordon most common in: | women & obese pts
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| SCC prevalence | 20% of all skin ca
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| Keratoacanthoma epi: | M>F, usually patients >50 yo
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| Most common type of malig melanoma | Superficial Spreading MM (70-80% of all melanoma)
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| Superficial Spreading malig melanoma: Most common in: | Caucasians; usu seen on the trunk and extremities
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| Acral Lentiginous malig melanoma: epi | Most common MM in Asian-Americans / AA (>50% of all melanoma in these pops); Least common type of MM in Caucasians; 7% of all MM; M>F
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| __% of SLE patients have discoid lesions | 25%
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| Skin involvement occurs in __% of sarcoid patients | 25%
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| Rosacea epi | F>M; 30-50 yo; peak 40-50; esp Celtics
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| urticaria/angioedema most common when | 3rd-4th decade
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| scleroderma epi | F>M; 20-50 yrs
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| necrobiosis (NLD) incidence: | 2% of diabetics; female > male
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| Erythema nodosum: epi | 18-30 year olds; F>M; poss assoc w/leukemia
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| psoriasis epi | 2.1% of US adults (4.5M); 1M psoriatic arthritis; 200K new cases/yr
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| pemphigus vulgaris | middle aged; Jewish/mediterranean
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| melanoma numbers | 3% of skin ca; 66% of skin ca deaths
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| Paget dz | 1-2% adults; 5-11% of >80; elderly in NE; FH; 1-3% develop osteosarcoma
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| most common Male cancer | prostate ca (2d M ca COD)
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| thalassemia | alpha: SE Asian, Chinese; beta: mediterranean
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| Sickle cell dz | 8% carry Hgb S gene (trait); 1 in 400 births have SCD; onset in 1st yr (Hgb F falls); 40-50 yr life exp
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| most prevalent leukemia = | CLL: 2:1 M:F; inc w/age; median onset 65 yo
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| CML epi | young & middle age (55 yo); >80% survival 6 yrs
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| Hodgkin dz epi | 2 peaks: 15-45 yo (M>F) & >50 yo; 7900 new cases/yr
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| NHL epi | 20-40 yo; HIV/immunodef or exp to pesticides/solvents; 50K cases/yr
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| G6PD def prevalence | >200M worldwide (usu AA men); X linked recessive; females rare
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| Most common hereditary hyper-coagulable state; mainly ltd to ? | Factor V Leiden; pts of Euro extraction
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| Myelofibrosis peak incidence & survival | 50-70 yrs old; median survival is 2-5 yr from onset; occurs in 10 to 30% of pts w/P. vera
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| Factor IX def prevalence | AKA hemophilia B (Xmas dz); 1:30,000 live births; primarily in males
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| Factor VIII def prevalence | AKA hemophilia A; 1:5,000 live births; primarily in males
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| P. vera: incidence/prevalence | 60-70 yrs (mean dx age 65 yo; rare <40); M:F 1.2:1
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| esoph ca epidemiology | Squamous cell AA>W (EtOH / tobacco); adenocarcinoma W>AA (Barrett esoph)
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| colorectal ca prevalence | 60,000 d/yr; 3d leading COD
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| bladder ca | 98% are TCC; 3% of ca deaths in US; 3:1 M:F; 40-70 yo
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| most common renal malig: | RCC (renal cell ca): 3% of all adult cancers; usu AA, M, >55 yo
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| most common peds solid tumor: | Wilms tumor
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| most common malig in young men: | testicular ca
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| CKD: 5 yr survival rate = | 35%
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| glomerulonephritis | 60% kids (2-12 yo)
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| most common nephritic syndrome | IgA nepropathy; uncommon in AA, common in Asians; Cirrhosis, Celiac Disease, HIV, CMV
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| ADPKD | most common PKD type (> ARPKD => neonatal M&M, short life exp); usu bilateral; sxs in 4th decade
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| MS epidemiology | F>M; 350K in US (1M world); onset 20-40 yo; most present w/relapsing form; prevalence increases with distance from equator
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| Glioblastoma multiforme (GBM) epi | 50% of Astros; >60 yo; rare <30; 1 yr survival
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| Primary CNS lymphomas: incidence increased in: | Immunodef pts; AIDS; Organ TP; older pt
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| Bell palsy | 60% R sided; more often in PG, DM; assoc w/trauma, infxn, neoplasia, toxins
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| Parkinson dz: epi | 500,000 in US; 58 yo ave onset
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| myasthenia gravis | younger women & older men
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| half of trauma related deaths in young people are: | head injuries
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| Spinal cord injury overall incidence | 4/100,000 per year
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| kidney stones M:F | 3:1 M:!
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| ARPKD prevalence | 1 in 20,000 live births. Often diagnosed in neonatal period
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| Prostate cancer | Most common ca in men (no 2 cause of ca death in men). 160,000 cases/yr. AA>white.
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| Osteoscarcoma | Most common primary malignant bone tumor (20-30% of all). 70% are metastatic or hematologic origin. 3:2 M:F. Mostly adolescents. 2nd peak in 50-60 yo if hx of XRT
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| Anatomic incidence of osteosarcoma | 90% in metaphyseal region of long bones (50% of these around knee).
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| Alzheimer | 60-70% of dementias. 5.3M people in US (to 14M by 2040).
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