Epidemiology: Rheum, Arthritides, Endocrine
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| Sarcoid prevalence | Swedes, Danes, AA; F>M
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| Sarcoid lifetime risk | 0.85% (W); 2.4% (AA)
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| Sarcoid mortality | d/t resp fail = 1-5%
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| SLE epi | US: 15-50/100k (MC AAF); 3x in 40 yrs; 90% F; M = less photosensitivity, more serositis; Elderly: milder dz; 65% 16-55 yo; urban > rural
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| Most common connective tissue disorder involving the esophagus: | Scleroderma esophagus (atrophy & fibrosis of esophageal smooth mx)
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| Polymyositis/Dermatomyositis epi | 2 peaks (kids; >50 yo); very rare; often assoc w/malig (esp DM) & other autoimm dz; PM 3:1 F:M
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| Inclusion Body Myositis (IBM): Epi | In pts >50yrs: most common inflam myopathy; M 2X F
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| Scleroderma Epi | F 3-4 x M; US: 10-20/ million; age, gender & ethnic sig factors in suscept; more common in AA pts; usu 3d / 4th decade
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| Giant cell arteritis Epi | White; >50 yo; F:M = 2:1
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| polyarteritis nodosa | 3:1 M:F, onset usu 40-60 yo; 30% assoc w/hep B
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| Diabetes Mellitus: incidence of acute life threatening complications | DKA ( 4.6-8 episodes per 1000 pts w/ DM); hyperglycemic hyperosmolar syndrome (HHS: < 1% of all primary DM admissions)
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| Gout epi | M 40-50 yo; F 65 yo; genetic, environmental
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| Prevalence inflammatory arthritis in IBD pts | 30-35%
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| Spondylo prevalence | 2:1000; usu adolescence or early adulthood
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| OA prevalence: | 60-90% of >65; 1 in 5 adults; onset 40-60 yo; 3:1 F:M; knee OA most common cause LT disability in US
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| Inf arthritis incidence | 2-5/100,000 (bimodal: kids, >50 yo) (in RA: 28-38/100,000)
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| Gono arthritis: incidence | 2/3 of infxs arth in pts <40; DGI sequela; F>M (higher risk w/ menses & PG)
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| RA epi | Worldwide: 0.8% adult; 3:1 F:M; peak onset 25-55 yo; 3-5 yr reduction in life exp; Incidence is declining
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| Osteoporosis | F>M (4:1); 1.7M fx in US; 6M hip fx world; W&Asian > Hisp > AA; 4 in 10 WF will fx
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| Androgen-secreting adrenal ca prevalence | More common than adenomas
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| most common thyroid neoplasm | papillary (75-80%); 3:1 F:M, inc w/age; other: follicular, medullary, anaplastic
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| Hypothyroid prevalence | 2% of US F (0.2% US M); 1 in 4000 newborns
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| Graves dz | 6:1 F:M. 20-40 yo. +FH. comorbid w/other autoimmune dz or Addison, celiac, cardiomyopathy
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| Most common cause of hyperthyroidism in US = | Graves dz
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| Most common thyroid disorder in US = | Hashimoto (chronic) thyroiditis: 1% (5% of >65yo); FH, 6:1 F:M, hep C
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| medullary thyroid ca | 1/3 sporadic, 1/3 familial, 1//3 MEN2
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| Most common Diabetes Mellitus complication | neuropathy
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| Pheochromocytoma | 90% benign, 10% malignant. Found in 0.1-0.5% of HTN pts. May be part of MEN syndromes
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| What % of Diabetes Mellitus pts have T2DM? | 90% (of those, 75-80% associated with obesity)
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